ETHANOLIC EXTRACT OF MORINGA OLEIFERA ALLEVIATES THE SYMPTOMS OF MIGRAINE-LIKE BEHAVIOR IN RATS

Strany: 75 - 90

Jazyk: eng

Objective: This study aimed to investigate the potential efficacy of Moringa oleifera ethanolic extract in alleviating migraine pain at different doses. Background: In this study, we employed an in vivo rat model in which systemic administration of nitroglycerin (NTG) was used to induce migraine-like and headache-like behaviors. Methods: Forty rats were randomly assigned to five groups (n = 8 per group): control (CT), NTG-only, sumatriptan (SMT), M. oleifera 50 mg/kg (MO 50 mg/kg), and MO 100 mg/kg. NTG (10 mg/kg, intraperitoneally) was administered every other day for nine days to induce migraine-like symptoms. Behavioral assessments—including climbing, face rubbing, body grooming, freezing, and head scratching—were conducted over a 60-minute period following NTG administration. Two hours post-treatment, the animals were sacrificed, and blood and hippocampal tissue samples were collected. Antioxidant activity, inflammatory biomarker expression (via enzyme-linked immunosorbent assay), and brain-derived neurotrophic factor (BDNF) levels were analyzed. Results: Our findings indicate that M. oleifera ethanolic extract at 50 mg/kg exhibited headache-relieving properties, enhanced BDNF levels, and mitigated depression-like behavior and anxiety indices. However, it did not significantly reduce inflammatory cytokines such as IL-6 and hs-CRP compared to the CT group. Notably, SOD activity was higher in the MO 50 and MO 100 mg/kg groups than in the SMT and NTG groups, although the CT group maintained the highest levels. Conclusions: These findings suggest that M. oleifera demonstrates significant migraine-relieving effects compared to sumatriptan, with a more favorable safety profile, making it a promising candidate for migraine management.

ISO 690:

Modarresi Chahardehi, A., Hosseini, Y., Navabi, Y., Chamanara, M. 2025. ETHANOLIC EXTRACT OF MORINGA OLEIFERA ALLEVIATES THE SYMPTOMS OF MIGRAINE-LIKE BEHAVIOR IN RATS. In Activitas Nervosa Superior Rediviva, vol. 67, no.2, pp. 75-90. 1337-933X. DOI: https://doi.org/10.31577/ansr.2025.67.2.4

APA:

Modarresi Chahardehi, A., Hosseini, Y., Navabi, Y., Chamanara, M. (2025). ETHANOLIC EXTRACT OF MORINGA OLEIFERA ALLEVIATES THE SYMPTOMS OF MIGRAINE-LIKE BEHAVIOR IN RATS. Activitas Nervosa Superior Rediviva, 67(2), 75-90. 1337-933X. DOI: https://doi.org/10.31577/ansr.2025.67.2.4

Vydavateľ: Centrum Experimentálnej Medicíny SAV, v. v. i.