Subclinical hypothyroidism in combination with vitamin D deficiency increases the risk of impaired left ventricular diastolic function

Rok, strany: 2015, 84 - 90

Subclinical hypothyroidism and vitamin D deficiency are common. The diastolic function of patients with both subclinical hypothyroidism and vitamin D deficiency remains unknown. This study aimed to investigate diastolic dysfunction in patients with both subclinical hypothyroidism and vitamin D deficiency. This study included 254 patients. All patients underwent standard Doppler echocardiography. Patients who had risk factors for diastolic dysfunction or had used L-thyroxine and vitamin D within the previous 3 months were excluded. Vitamin D deficiency was defined as a 25-OH-vitamin D level lower than 20 ng/ml, and vitamin D sufficiency was defined as a 25-OH-vitamin D level ≥30 ng/ml. Subclinical hypothyroidism was defined as a TSH level of 4.5-10 mU/l when the free T4 concentration was normal. The patients were divided into 4 groups. Group 1 (n=71) included patients with subclinical hypothyroidism and vitamin D deficiency; Group 2 (n=66) included patients with subclinical hypothyroidism and vitamin D sufficiency; Group 3 (n=65) included euthyroid patients with vitamin D deficiency; and Group 4 (n=52) included euthyroid patients with vitamin D sufficiency. LAVI (31.3±3.2, 28.7±3.0, 28.4±3.4, and 27.9±3.9; p<0.001) and E/E’ values (11.2±2.7, 8.9±2.7, 9.1±2.9, 8.8±2.5; p<0.001) were significantly higher in Group 1 than in Groups 2, 3 and 4. E’ values were significantly lower in Group 1 than in Groups 2, 3 and 4. The coexistence of subclinical hypothyroidism with vitamin D deficiency can lead to further deterioration in the LV diastolic function via the regulation of intracellular calcium and induction of inflammatory activity. Therefore, close follow-up of the diastolic functions of these patients could be beneficial.

ISO 690:

Yilmaz, H., Cakmak, M., Darcin, T., Inan, O., Gurel, O., Bilgic, M., Bavbek, N., Akcay, A. 2015. Subclinical hypothyroidism in combination with vitamin D deficiency increases the risk of impaired left ventricular diastolic function. In ENDOCRINE REGULATIONS, vol. 49, no.2, pp. 84-90. 1210-0668. DOI: https://doi.org/10.4149/endo_2015_02_84

APA:

Yilmaz, H., Cakmak, M., Darcin, T., Inan, O., Gurel, O., Bilgic, M., Bavbek, N., Akcay, A. (2015). Subclinical hypothyroidism in combination with vitamin D deficiency increases the risk of impaired left ventricular diastolic function. ENDOCRINE REGULATIONS, 49(2), 84-90. 1210-0668. DOI: https://doi.org/10.4149/endo_2015_02_84

Vydavateľ: AEPress, s.r.o.