Stability studies of endocrine disrupting tributyltin and triphenyltin compounds in an artificial sea water model

Rok, strany: 2018, 93 - 99

Triorganotins belong to toxic components present predominantly in antifouling paints for marine vessels. Tributyltin/triphenyltin at pico- or nanomolar concentrations in sea water are known to induce an irreversible sexual abnormality in females of over 190 marine species, an "imposex" phenomenon – the superimposition of male genitalia on a female. Moreover, trialkyltins and triaryltins function as potent nuclear retinoid X receptors (RXR) agonists. In mammals, triorganotin compounds induce immunosuppressive, metabolic, reproductive or developmental effects. Toxic effects of triorganotins warrant the need for monitoring of their long-lasting presence in the environment. This study brings novel data on the stability of two triorganotin compounds in artificial sea water model obtained by applying ultra-pressure liquid chromatography (UPLC) and gas chromatography-mass spectrometry (GC-MS) methods. Stability of tributyltin and triphenyltin chlorides was studied for 180 days and the degradation kinetic parameters were obtained. Tributyltin chloride was the less stable with the degradation kinetic parameters Kdeg = 0.00014 day–1 and t1/2 = 4950 days (13.6 years). Kdeg of the more stable triphenyltin chloride was determined to be Kdeg = 0.00006 day–1 with t1/2 = 11550 days (31.6 years). Since similar stability data of triorganotin compounds were not published previously, we report high stability for both tested compounds, which indicates a significant environmental problem when these substances enter sea water and later coastal sediments.

ISO 690:

Novotny, L., Sharaf, L., Abdel-Hamid, M., Brtko, J. 2018. Stability studies of endocrine disrupting tributyltin and triphenyltin compounds in an artificial sea water model. In General Physiology and Biophysics, vol. 37, no.1, pp. 93-99. 0231-5882.

APA:

Novotny, L., Sharaf, L., Abdel-Hamid, M., Brtko, J. (2018). Stability studies of endocrine disrupting tributyltin and triphenyltin compounds in an artificial sea water model. General Physiology and Biophysics, 37(1), 93-99. 0231-5882.