Information Page of SAS Organisation

Institute of Measurement Science

International projects

European network for advancing Electromagnetic hyperthermic medical technologies.
Európska sieť pre pokrok v elektromagnetických hypertermických medicínskych technológiách
Program: COST
Project leader: Mgr. Teplan Michal PhD.
Annotation:Electromagnetic (EM) hyperthermic technologies hold great potential in the treatment of diseases, especially for cancers that are resistant to standard regimens. These technologies modify tissue temperature: hyperthermia heats the diseased tissue to make it susceptible to treatments, and ablation heats the tissue until it is destroyed. Hyperthermia is particularly effective in treatment of cervical and breast cancer, head and neck cancers, sarcoma in adults, and germ cell tumours in children; while radiofrequency and microwave ablation offer promise for treating liver, kidney, and lung cancers. Overall, these techniques have shown significant potential and there is substantial opportunity to solidify their use clinically and to apply them to a wider range of medical conditions. However, underpinning the development of these techniques is the need for accurate knowledge of the dielectric and thermal properties of tissues, which provide the foundation for these technologies and de-risk the technical challenge before commercialization. Furthermore, contributing to the stagnant market of EM hyperthermic medical devices is the fact that, often researchers working on the development of medical technologies are not fully aware of, and not trained to address, the clinical and commercialisation challenges facing novel medical devices. To address these challenges, the MyWAVE Action takes a holistic approach by bringing together key players in the field of dielectric spectroscopy, translational research, and medical professionals. Conjoining these varied communities into one collaborative network is critical to advance the design, development, and commercialisation of EM hyperthermic technologies, so that they can reach patients faster and improve treatment outcomes.
Project web page:www.cost.eu/actions/CA17115
Duration: 4.9.2018 - 3.9.2022

KZM - Comparative imaging methods based on magnetic resonance
Komparatívne zobrazovacie metódy na báze magnetickej rezonancie
Program: Bilaterálne - iné
Project leader: Prof. Ing. Frollo Ivan DrSc.
Annotation:Research of comparative imaging methods based on magnetic resonance for diagnostics of neurological and musculoskeletal diseases. Imaging of micro- and nanostructures based on magnetic resonance for biomedical and material research. Mutual visits of scientists and PhD students enabling them to perform imaging experiments on MRI instruments in the laboratories of partners in the appropriate time limits.
Duration: 1.3.2017 - 31.12.2020

COMULIS - Correlated Multimodal Imaging in Life Sciences
Korelované multimodálne zobrazovanie vo vedách o živej prírode
Program: COST
Project leader: RNDr. Hain Miroslav PhD.
Annotation:The network aims at fueling urgently needed collaborations in the field of correlated multimodal imaging (CMI), promoting and disseminating its benefits through showcase pipelines, and paving the way for its technological advancement and implementation as a versatile tool in biological and preclinical research. CMI combines two or more imaging modalities to gather information about the same specimen. It creates a composite view of the sample with multidimensional information about its macro-, meso- and microscopic structure, dynamics, function and chemical composition. Since no single imaging technique can reveal all these details, CMI is the only way to understand biomedical processes and diseases mechanistically and holistically. CMI relies on the joint multidisciplinary expertise from biologists, physicists, chemists, clinicians and computer scientists, and depends on coordinated activities and knowledge transfer between academia and industry, and instrument developers and users. Due to its inherently multidisciplinary and cross-functional nature, an interdisciplinary network such as this Action is indispensable for the success of CMI. Nevertheless, there is currently no European network in the field. Existing scattered efforts focus on correlated light and electron microscopy or (pre)clinical hybrid imaging. This Action will consolidate these efforts, establish commonly-accepted protocols and quality standards for existing CMI approaches, identify and showcase novel CMI pipelines, bridge the gap between preclinical and biological imaging, and foster correlation software through networking, workshops and open databases. The network will raise awareness for CMI, train researchers in multimodal approaches, and work towards a scientific mindset that is enthusiastic about interdisciplinary imaging approaches in life sciences.
Project web page:https://e-services.cost.eu/action/CA17121
Duration: 1.1.2019 - 11.10.2022

MULTI-FORESEE - MULTI-modal Imaging of FOREnsic SciEnce Evidence (MULTI-FORESEE) - tools for Forensic Science
Multimodálne zobrazovanie dôkazov forenznej vedy - nástroje pre forenznú vedu
Program: COST
Project leader: RNDr. Hain Miroslav PhD.
Annotation:The main objective is to promote innovative, multi-informative, operationally deployable and commercially exploitable imaging solutions/technology to analyse forensic evidence. Forensic evidence includes, but not limited to, fingermarks, hair, paint, biofluids, digital evidence, fibers, documents and living individuals. Imaging technologies include optical, mass spectrometric, spectroscopic, chemical, physical and digital forensic techniques complemented by expertise in IT solutions and computational modelling. Imaging technologies enable multiple physical and chemical information to be captured in one analysis, from one 'specimen', with information being more easily conveyed and understood for a more rapid exploitation. The ‘enhanced’ value of the evidence gathered will be conducive to much more informed investigations and judicial decisions thus contributing to both savings to the public purse and to a speedier and stronger criminal justice system. Lack of knowledge sharing, standardised protocols and communication between Academia, End Users and industry has been a barrier to translational science in this field; the Action will use the unique networking and capacity-building capabilities provided by the COST framework to bring together their knowledge and expertise; this is paramount to engage in a synergistic approach to boost imaging technological developments, allowing scientifically sound, highly reliable and multi-informative intelligence to be provided to investigators, prosecutors and defence. COST support is crucial to conquer the challenge on short term basis and to provide a legacy to Europe to advance knowledge for the deployment of cutting edge, innovative and implementable imaging forensic science.
Project web page:https://www.cost.eu/actions/CA16101
Duration: 1.8.2018 - 1.3.2021

Wearable Robots for Augmentation, Assistance or Substitution of Human Motor Functions
Nositeľné robotické zariadenia pre posilnenie, podporu alebo náhradu motorických funkcií človeka
Program: COST
Project leader: Doc. Ing. Přibilová Anna PhD.
Annotation:Wearable Robots (WRs) is an emerging field of personal devices that are integrated parts of human functioning, and that are constructed of typical robotic components such as actuators, sensors and control algorithms. Where conventional robots were typically intended for use in industrial environments to help in tedious and repetitive tasks and tasks requiring high precision, the situation is currently evolving to one where there is an increasing direct physical interaction between robot and human operator. The interaction with humans in WRs is not only physical, but also includes cognitive aspects, as in the interaction, control of functions is typically shared by human and machine. WRs can be used either to augment, train or supplement motor functions or to replace them completely. Wearable Robots operate alongside human limbs, as is the case in orthotic robots, exoskeletons or robotic suits. WRs are expected to find applications in Medical, Industrial and Consumer Domains, such as neuro-rehabilitation, worker support, or general augmentation. As WRs continuously interact with humans in multiple situations, Human Robot Interaction, Ergonomics, and Ethical, Legal and Societal (ELS) considerations, as well as early involvement of stakeholders are of essential interest. This Action focuses on the European integration of different underlying disciplines in science and engineering, as well as on engaging of stakeholders to improve WR technology and its societal impact.
Project web page:https://www.cost.eu/actions/CA16116
Duration: 15.3.2017 - 14.3.2021

Novel integrated approaches for research of biomedical effects of pulsed electric fields
Nové integrované prístupy pre výskum biomedicínskych účinkov pulzných elektrických polí
Program: Medziakademická dohoda (MAD)
Project leader: Mgr. Teplan Michal PhD.
Annotation:Intense pulsed electric fields have already use and great further potential for novel applications in biomedicine and food industry. However, the mechanistic details of the action of pulsed electric fields on the plasma membrane and especially on the intracellular level are still not clear. This project is focused on theoretical and experimental characterization of the effects of pulsed electric fields from the level of subcellular biomolecular structures to a cellular level. We aim to develop and employ approaches based on impedance spectroscopy and chemiluminescence detection which will enable us to explore the most prominent bioeffects of pulsed electric fields in a real-time, non-invasive and label-free manner. The major technological novelty will be in the integration of these monitoring tools to an automatic programmable experimental platform. The results of the project will provide new methods in the research of effects of electromagnetic fields on living cells and will bring future medical applications closer to reality.
Duration: 1.1.2018 - 31.12.2020

Understanding and modeling compound climate and weather events
Porozumenie a modelovanie združených klimatických a meteorologických javov
Program: COST
Project leader: Mgr. Chvosteková Martina PhD.
Annotation:Hazards such as floods, wildfires, heatwaves, and droughts usually result from a combination of interacting physical processes that occur across multiple spatial and temporal scales. The combination of physical processes leading to an impact is referred to as a Compound Event. Examples of high-impact Compound Events include (i) droughts, heatwaves, wildfire and/or air pollution and their interactions involving a complex interplay between temperature, humidity and precipitation; (ii) extreme precipitation, river discharge and storm surge interactions, combining coastal storm processes with fluvial/pluvial and ocean dynamics; (iii) storms including clustering of major events leading to spatial and/or temporal dependence. Climate change alters many of these processes and their interaction, making projections of future hazards based on single driver analyses difficult. Impact studies considering only one driver usually fail to assess the extent of the impacts of Compound Events. It is thus not clear whether climate models can capture major changes in risk associated with Compound Events. Existing modelling approaches used to assess risk may therefore lead to serious mal-adaptation. DAMOCLES will (a) identify key process and variable combinations underpinning Compound Events; (b) describe the available statistical methods for modelling dependence in time, space, and between multiple variables; (c) identify data requirements needed to document, understand, and simulate Compound Events, and (d) propose an analysis framework to improve the assessment of Compound Events. DAMOCLES brings together climate scientists, impact modellers, statisticians, and stakeholders to better understand, describe and project Compound Events, and foresees a major breakthrough in future risk assessments.
Project web page:https://www.cost.eu/actions/CA17109
Duration: 14.9.2018 - 13.9.2022

Preparation and study of the precursor properties for development of nanomaterials based on metal oxides
Príprava a štúdium vlastností prekurzorov pre vývoj nanomateriálov na báze oxidov kovov
Program: Bilaterálne - iné
Project leader: RNDr. Cigáň Alexander CSc.
Annotation:The subject of common interest include the following main areas: 1. Technology of HTc superconducting oxides based on Yttrium, Bismuth, Thalium and Mercury - bulks, tapes and thin films. 2. Investigation of the physical properties of these materials with the help of magnetization measurements. 3. Common experiments performed with LTc SQUID gradiometric system (at IMS SAS, Bratislava) and LakeShore susceptometer (at the Department of Inorganic and Physical Chemistry, Ghent). 4. Publication of results on cooperative scientific activities.
Duration: 1.7.2016 - 31.12.2020


National projects

Analysis of multivariate time series and its application to research of functional connectivity in the brain
Analýza viacrozmerných časových radov a jej aplikácie na výskum funkčných prepojení v mozgu
Program: VEGA
Project leader: RNDr. Krakovská Anna CSc.
Annotation:The project is focused on the analysis of complex experimental time series. Applications will mainly concern the multi-channel electroencephalographic (EEG) signals measured from the human brain. We will be interested in functional connectivity between brain regions. The time series will not be examined in isolation, but as one of the manifestations of a complex system or subsystem. The analysis of simultaneously measured signals should help trace areas in the brain that are relatively independent or synchronized or causally affected by each other. Our focus will be on brain functional state changes during experiments focused on monitoring selected cognitive processes. We will also deal with the hypothesis of self-organized, scale-free, fractal processes in brain functioning. In terms of methodology, we would like to contribute to the development of multivariate causal methods, algorithms for multidimensional statistical analysis, and machine learning methods for the processing and analysis of EEG signals.
Duration: 1.1.2019 - 31.12.2021

Measurement and modeling of the cardiac electrical field for noninvasive identification and interpretation of structural changes of the ventricular myocardium leading to ventricular arrhythmias
Meranie a modelovanie elektrického poľa srdca na neinvazívnu identifikáciu a interpretáciu štrukturálnych zmien komorového myokardu vedúcich k ventrikulárnym arytmiám
Program: VEGA
Project leader: Ing. Švehlíková Jana PhD.
Annotation:The project is focused on the research of the measuring methods and processing of the electrical manifestation of the heart activity with the aim to diagnose myocardial structural changes or origins of the ventricular arrhythmias noninvasively. The main goal is a robust inverse solution for noninvasive localization and characterization of the origin of premature ventricular complexes and obtaining relevant medical information for radiofrequency ablation therapy. One part of the solution will be the methods for pathological heart activation modeling and computation of the potentials on the individual torso surface. The selection of an electrical generator model, heart activation process, and electrical parameters of the anisotropic torso allow optimization of the forward and inverse solution. To achieve the goals, advanced methods for ECG signals variability analysis as well as parallel computational methods will be proposed. A concept of ECG measuring system with a wireless data transfer will be developed.
Duration: 1.1.2019 - 31.12.2021

Morfology of fossil lizards using micro-computed tomography, their phylogeny, paleobiogeography - migrations and faunal changes during the climatic changes of Cenozoic
Morfológia fosílnych jašterov s použitím zobrazovacích techník počítačovej mikrotomografie, ich fylogenetické vzťahy, paleobiogeografia - migrácie a zmeny spoločenstiev odrážajuce postupné klimatické zmeny kenozoika
Program: VEGA
Project leader: RNDr. Hain Miroslav PhD.
Annotation:Project deals with new, in most cases complete finds of lizards from the Cenozoic, which is a period characterized by marked global climate changes. The aim is the anatomical research of fossil and modern animals using micro-CT.
Duration: 1.1.2018 - 31.12.2020

New statistical methods for special families of probability distributions and their applications
Nové štatistické metódy pre špeciálne triedy rozdelení pravdepodobnosti a ich aplikácie
Program: VEGA
Project leader: Doc. RNDr. Witkovský Viktor CSc.
Annotation:The project analyzes special classes of probability distributions. New statistical methods for distributions from these classes are suggested and theoretically characterized, namely, parameter estimations, goodness of fit tests, and parametric and non-parametric statistical inference. This statistical apparatus is then applied to specific problems in metrology, insurance and financial mathematics, linguistics and demography. As a part of the project, computational methods and algorithms are constructed for these statistical procedures.
Duration: 1.1.2018 - 31.12.2020

ReSynCard - Personalized Optimisation of Cardiac Resynchronization Therapy in Heart Failure Based on Multiple Lead ECG Measurement
Personalizovaná optimalizácia resynchronizačnej liečby srdcového zlyhávania na základe mnohozvodového merania EKG
Program: APVV
Project leader: Doc. Ing. Tyšler Milan CSc.
Annotation:Cardiac resynchronization therapy (CRT) is currently the most advanced therapeutic method for treatment of patients with failing heart. The essential criteria for patient indication for CRT are based on standard 12-lead ECG and echocardiographic measurements and include ECG pattern of left bundle branch block, prolongation of the QRS time interval, and left ventricular ejection fraction less than 35%. Despite most patients have a great benefit from the CRT, still 20-40% of patients do not profit from the therapy. On the other side, there is a considerable number of positive responders among patients not fulfilling the criteria. Therefore, there is a great effort to increase the success rate of the intervention and to find better criteria for its application. Current research shows that surface ECG maps recorded by a large number of electrodes, ECG imaging solving the inverse problem of electrocardiology and reconstructing the electrical activity of the heart, or combination of ECG imaging with computed tomography to identify structural damage of the myocardium have potential for more reliable detection of the electrical dyssynchrony and for suggesting optimal electrode placement and their timing. The main objective of the project is the research of methods for personalized optimization of the CRT therapy based on multi-lead surface ECG measurement and their verification on simulated data and data from real patients. The partial aims include: • finding such body surface potential maps parameters that could serve as suitable indicators of the electrical dyssynchrony of ventricles, • design of an inverse method for noninvasive localization of the latest activated areas in the ventricles and their use for placing the electrode in the left ventricle, • simulation of failing heart activation to understand the undergoing processes and their reflection in surface ECG signals, • development of a dedicated multi-lead ECG measuring system for personalized CRT optimization.
Duration: 1.7.2020 - 30.6.2023

Origin of amniotes: identification of key structures of the most-basal amniotes using computed microtomography
Pôvod amniótov: identifikácia kľúčových štruktúr najbazálnejších amniótov využitím počítačovej mikrotomografie
Program: VEGA
Project leader: RNDr. Hain Miroslav PhD.
Annotation:Our knowledge of the skeletal structures, on the basis of which it is possible to identify the most-basal amniotes, will be focused on the study: 1) of stem amniotes having an amphibian reproductive strategy, and 2) of the basal amniotes with the terrestrial reproductive strategy. Besides this, the investigation will be focused on the Parmo-Carboniferous group Diadectomorpha, the members of which play a key role as for the origin of amniotes. The first aim of the project is the knowledge of morphological transformations of the neurocranial structures during the evolutionary transition of tetrapods with amphibian reproductive strategy (Anamnia, the reproduction depending on external water) to tetrapods with reproduction not more depending on external water (Amniota, they leg the amniotic eggs on the land). The second aim is to evaluate all gained morphological data in the phylogenetic analysis to resolve the relationships of the investigated taxa at the transition stem amniotes – basal crown amniotes.
Duration: 1.1.2019 - 31.12.2021

Effect of ultrasmall superparamagnetic iron oxide nanoparticles on the cardiovascular system of rats with high blood pressure
Vplyv ultra malých superparamagnetických nanočastíc železa na kardiovaskulárny systém potkana v podmienkach vysokého krvného tlaku
Program: VEGA
Project leader: Ing. Maňka Ján CSc.
Annotation:This project will investigate the effect of ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on function and structure of the arterial wall and the heart in rats with high blood pressure. We will investigate if acute stress and chronic high blood pressure can facilitate the USPIONs uptake in the arterial wall and heart, to modify cardiovascular function, including blood pressure regulation and to induce metabolic disorders, oxidative damage and alterations of the Fe2+/Fe3+ ratio in the heart and vasculature. We will investigate if L-type of voltage-dependent calcium channels is involved in iron uptake after USPIONs treatment. Results achieved in this project will contribute to better understanding of USPIONs effects on the cardiovascular system in conditions of acute stress and high blood pressure as well as on prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery.
Duration: 1.1.2017 - 31.12.2020

ECoReMiR - Enhancing cognition and motor rehabilitation using mixed reality
Vylepšovanie kognície a motorickej rehabilitácie s využitím zmiešanej reality
Program: APVV
Project leader: Ing. Mgr. Rosipal Roman PhD.
Annotation:Technological advancements based on mixed reality (MR) offer various challenges for research and medical treatment. The project focuses on two objectives related to healthy subjects and hemiparetic patients after stroke. First, we will test the hypothesis whether cognitive training using appropriately designed MR environment will enhance perceptual and cognitive performance in healthy subjects. This will be tested by computerized psychological experiments as well as by measuring event-related potentials or ERPs. Second, we will test the hypothesis whether experience with training in MR (in combination with motor-imagery based brain-computer interface developed by us) will enhance oscillatory sensory-motor rhythms. This will be tested by measuring subject’s EEG activity before and after each training session, clinical testing, as well as by the questionnaires aiming to learn about human factors including mental fatigue, motivation, irritation or sleepiness due to training. In both objectives, we will design and implement a set of testing procedures, carry out a battery of dedicated experiments, and critically evaluate the results with the goal to validate MR designs.
Duration: 1.7.2017 - 30.6.2021

RIDD - Research of magnetic forms of iron in development of cardiovascular diseases and behavioural disorders
Výskum magnetických foriem železa v rozvoji kardiovaskulárnych chorôb a porúch správania
Program: APVV
Project leader: Ing. Maňka Ján CSc.
Annotation:This project proposal is focused on the investigation of the role of iron in development of cardiovascular and behavioural disorders, prevalence of which is increasing during aging. The aim of this project is to investigate the impact of aging on the metabolism of biogenic iron and its magnetic properties in association with metabolic and functional alterations in the cardiovascular system and brain in rats with various genetic predispositions to hypertension. We will determine the molecular biological changes on the level of gene expression, their encoded proteins and the activities of the enzymes involved in the endogenous antioxidant protection, the regulation of nitric oxide production and cell death due to ferroptosis in course of aging. We will also investigate the impact of exogenously administered iron in the form of the biocompatible ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on blood pressure regulation and function of the heart and blood vessels in conditions of normotension, chronically increased blood pressure and acute stress (i.e. acutely elevated blood pressure). Results achieved in this project will contribute to better understanding of the effects of the altered iron metabolism, magnetic forms of bodily iron, as well as iron in the form of USPIONs, on the cardiovascular and central nervous systems and to prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery or as the contrast materials for new imaging methods in medicine.
Project web page:http://www.bionanoiron.sav.sk/
Duration: 1.7.2017 - 30.6.2021

Research on possibilities and development of SQUID magnetometry for selected applications in biomedicine and material research
Výskum možností a rozvoj SQUID magnetometrie pre vybrané aplikácie v biomedicíne a materiálovom výskume
Program: VEGA
Project leader: Ing. Maňka Ján CSc.
Annotation:Project has an interdisciplinary character.The aim is to show the possibilities of use of the SQUID magnetometry in study of the actual processes in medicine, biology and material research: -in analysis of the properties and magnetic characterization of the nanoparticles and nanoliquids, especially ultra-small superparamagnetic nanoparticles based on iron oxides (USPIONs) -in investigation of the influence of the USPIONs on the function and structure of the blood vessels and heart, on development of the oxidative damage and in study of processes of the USPIONs transport through cell membranes, blood vessels and organs of rats with normal and high blood pressure -in development of the procedures and methods of quantification of the magnetic substances content in the human and animal cell cultures and organs - in study and development of the aluminate glasses with photoluminescence properties - in development of new 2D materials, MXenes, exfoliated transition metal carbides and carbonitrides
Duration: 1.1.2017 - 31.12.2020

-
Vývoj a realizácia etalónu statického magnetického poľa na báze magnetickej rezonancie
Program: APVV
Project leader: Ing. Andris Peter PhD.
Duration: 1.7.2020 - 30.6.2023

Development of experimental platform and analytical tools for measurement of low frequency electromagnetic field effects on biological systems
Vývoj experimentálnej platformy a nástrojov analýzy na meranie účinkov nízkofrekvenčných elektromagnetických polí na biologické systémy
Program: VEGA
Project leader: Mgr. Teplan Michal PhD.
Annotation:The aim of the project is to develop measurement methods and analysis tools for identification of the effects of weak low frequency (LF) electromagnetic (EM) fields on selected biological systems. The main objective is the development of an automated experimental platform comprising multiple measurement stations, allowing monitoring and subsequent characterization of cell cultures. Main detection approaches include methods of impedance spectroscopy, turbidimetry, and optical microscopy. A complex hardware-software system will allow efficient scanning of frequencies and amplitudes of EM fields in order to identify parameters that lead to a specific response in the examined biosystems. Morphology and cell kinetics will be investigated by computer image analysis obtained from video-microscopy. The results will be analyzed for their possible applications in emergent problems of contemporary society.
Duration: 1.1.2019 - 31.12.2021

DIMPP - Development of innovative methods for primary metrology torque forces by force effects of the conventional standards
Vývoj inovatívnych metód pre primárnu metrológiu momentu sily aplikáciou silových účinkov konvenčnej etalonáže
Program: APVV
Project leader: Doc. RNDr. Witkovský Viktor CSc.
Annotation:Torque is one of the main indicators for testing, respectively. testing a wide range of rotating machines and equipment. Measurements in the area over the last decades show a growing trend in terms of both quantity and quality requirements. This factor is also contributing to the growth of the automotive industry in Slovakia. Measuring momentum is inherently related to metrological continuity and the development of both industrial and secondary metrology. At present, however, the SR does not have a laboratory which, with its technical equipment and metrological quality, represents the highest level of primary metrology. The momentary force calibration laboratories in the SR are forced to look for sources of metrological continuity abroad. The aim of the project is therefore to lay the foundations of primary momentum metrology.
Duration: 1.7.2019 - 30.6.2022

Imaging methods based on the magnetic resonance for medical diagnostics and materials research
Zobrazovacie metódy na báze magnetickej rezonancie pre medicínsku diagnostiku a materiálový výskum
Program: VEGA
Project leader: Ing. Andris Peter PhD.
Duration: 1.1.2020 - 31.12.2022

Projects total: 22