Institute of Experimental Physics
Effect of irradiation on protein-nanoparticle complexes
Physical engineering of modern materials
Name of the supervisor
doc. RNDr. Peter Kopčanský, CSc. ()
Faculty of Electrical Engineering and Informatics TUKE
A common feature associated with most of neurodegenerative diseases is the formation of extended, β-sheet rich amyloid fibrils. Today, amyloid-related diseases are incurable and the treatment is only symptomatic without feasibility to stop or substantially delay the progressive consequences of the diseases. Thus, nanoparticles are being explored for their role in diagnosing, preventing, treating or even causing amyloid diseases. Additionally, over the last decades, there was increased interest in the studies of in vitro and in vivo applications of NPs in radiation therapy. The proposed PhD study is aimed at basic research that may provide better understanding of the general effect of radiation, the interplay between proteins, NPs and radiation. Further investigations will help identify the role of radiation in the etiology of neurodegenerative diseases, because they are considered to be late effects of radiation. The proposed studies concentrate on the increase of the sensitivity of soft matter materials to magnetic fields, and the ultimate goal of the proposal is to make a step forward towards potential applications of prepared systems in various biomedical applications for drug delivery and what is more, enhanced destructive effect on amyloid aggregates using radiation. A great effort will be paid on study of the stability of amyloid aggregates when irradiated with external radiation with/without the presence of magnetic nanoparticles as well as on establishment of the protocol of “safe radiation doses”.