RNDr., Ing. Katarína Šipošová, PhD.
Senior Scientist
Watsonova 47
040 01 Košice
Slovak Republic
@:
Biophysicist and protein biochemist
• Master's degree in biochemistry received in 2009 at the P.J. Safarik University in Kosice
• PhD in biochemistry received in 2013 at the P.J. Safarik University in Kosice
• in 2017 she graduated in the field of Environmental Engineering at the Faculty of Metallurgy at the Technical University of Kosice
Research activities are mainly focused on the study of:
1 - the biochemical and biophysical properties of amyloid-prone proteins, associated with neurodegenerative diseases: i) identification of the conditions leading to the formation of protein amyloid aggregates and studying of morphological features of amyloid structures; ii) clarify the role of hydrophobic interactions in formation and stability of protein aggregates, particularly amyloid aggregates; iii) investigation of the interference of protein amyloid aggregation with low-molecular-weight compounds, peptides, and different nanoparticles; and iv) designing and development of a novel “drug delivery system”.
2 - Programmable self-organization of fibrils into nanostructured material for bioanalytical applications. The tasks are to: i) establish controllable “bottom-up” self-assembly of spider protein; 2) engineer spider-amyloid-based nanocomposites for biomedical and biotechnological applications.
Selected publications:
SIPOSOVA, K. - PETRENKO, V.I. – GARCAROVA, I. - SEDLAKOVA, D. - ALMASY, L. - KYZYMA, E.A. - KRIECHBAUM, M. - MUSATOV, A. The intriguing dose-dependent effect of selected amphiphilic compounds on insulin amyloid aggregation: Focus on a cholesterol-based detergent, Chobimalt. In Frontiers in Molecular Biosciences: open access, 2022, vol. 9, art. no. 955282.
HOVHANNISYAN, Vladimir - SIPOSOVA, Katarína - MUSATOV, Andrey - CHEN, Shean-Jen. Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia. Scientific Reports, 2021, vol. 11, no. 1, art. no. 5528.
SIPOSOVA, K. - KOZAR, T. - STUPAKOVA, M. - MUSATOV, A. Complementary experimental and computational analysis of the effects of non-ionic detergents and phospholipids on insulin amyloid aggregation. In Colloids and Surfaces B - Biointerfaces, 2021, vol. 197, art. no. 111428.
SIPOSOVA, K. - PETRENKO, V.I. - IVANKOV, O.I. - MUSATOV, A. - BULAVIN, L.A. - AVDEEV, M.V. - KYZYMA, E.A. Fullerenes as an Effective Amyloid Fibrils Disaggregating Nanomaterial. In ACS Applied Materials & Interfaces, 2020, vol. 12, no. 29, p. 32410-32419.
SIPOSOVA, K. - HUNTOSOVA, V. - SHLAPA, Y. - LENKAVSKA, L. - MACAJOVA, M. - BELOUS, A. - MUSATOV, A. Advances in the Study of Cerium Oxide Nanoparticles: New Insights into Antiamyloidogenic Activity. In ACS Applied Bio Materials, 2019, vol. 2, no. 5, p. 1884-1896.
SIPOSOVA, K. - KOZAR, T. - HUNTOSOVA, V. - TOMKOVA, S. - MUSATOV, A. Inhibition of amyloid fibril formation and disassembly of pre-formed fibrils by natural polyphenol rottlerin. In Biochimica et Biophysica Acta: proteins and proteomics, 2019, vol. 1867, no. 3, p. 259-274.
• Master's degree in biochemistry received in 2009 at the P.J. Safarik University in Kosice
• PhD in biochemistry received in 2013 at the P.J. Safarik University in Kosice
• in 2017 she graduated in the field of Environmental Engineering at the Faculty of Metallurgy at the Technical University of Kosice
Research activities are mainly focused on the study of:
1 - the biochemical and biophysical properties of amyloid-prone proteins, associated with neurodegenerative diseases: i) identification of the conditions leading to the formation of protein amyloid aggregates and studying of morphological features of amyloid structures; ii) clarify the role of hydrophobic interactions in formation and stability of protein aggregates, particularly amyloid aggregates; iii) investigation of the interference of protein amyloid aggregation with low-molecular-weight compounds, peptides, and different nanoparticles; and iv) designing and development of a novel “drug delivery system”.
2 - Programmable self-organization of fibrils into nanostructured material for bioanalytical applications. The tasks are to: i) establish controllable “bottom-up” self-assembly of spider protein; 2) engineer spider-amyloid-based nanocomposites for biomedical and biotechnological applications.
Selected publications:
SIPOSOVA, K. - PETRENKO, V.I. – GARCAROVA, I. - SEDLAKOVA, D. - ALMASY, L. - KYZYMA, E.A. - KRIECHBAUM, M. - MUSATOV, A. The intriguing dose-dependent effect of selected amphiphilic compounds on insulin amyloid aggregation: Focus on a cholesterol-based detergent, Chobimalt. In Frontiers in Molecular Biosciences: open access, 2022, vol. 9, art. no. 955282.
HOVHANNISYAN, Vladimir - SIPOSOVA, Katarína - MUSATOV, Andrey - CHEN, Shean-Jen. Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia. Scientific Reports, 2021, vol. 11, no. 1, art. no. 5528.
SIPOSOVA, K. - KOZAR, T. - STUPAKOVA, M. - MUSATOV, A. Complementary experimental and computational analysis of the effects of non-ionic detergents and phospholipids on insulin amyloid aggregation. In Colloids and Surfaces B - Biointerfaces, 2021, vol. 197, art. no. 111428.
SIPOSOVA, K. - PETRENKO, V.I. - IVANKOV, O.I. - MUSATOV, A. - BULAVIN, L.A. - AVDEEV, M.V. - KYZYMA, E.A. Fullerenes as an Effective Amyloid Fibrils Disaggregating Nanomaterial. In ACS Applied Materials & Interfaces, 2020, vol. 12, no. 29, p. 32410-32419.
SIPOSOVA, K. - HUNTOSOVA, V. - SHLAPA, Y. - LENKAVSKA, L. - MACAJOVA, M. - BELOUS, A. - MUSATOV, A. Advances in the Study of Cerium Oxide Nanoparticles: New Insights into Antiamyloidogenic Activity. In ACS Applied Bio Materials, 2019, vol. 2, no. 5, p. 1884-1896.
SIPOSOVA, K. - KOZAR, T. - HUNTOSOVA, V. - TOMKOVA, S. - MUSATOV, A. Inhibition of amyloid fibril formation and disassembly of pre-formed fibrils by natural polyphenol rottlerin. In Biochimica et Biophysica Acta: proteins and proteomics, 2019, vol. 1867, no. 3, p. 259-274.