RNDr., Ing. Katarína Šipošová, PhD.
Senior Scientist

Watsonova 47
040 01 Košice
Slovak Republic
@:
Biophysicist and protein biochemist
• Master's degree in biochemistry received in 2009 at the P.J. Safarik University in Kosice
• PhD in biochemistry received in 2013 at the P.J. Safarik University in Kosice
• in 2017 she graduated in the field of Environmental Engineering at the Faculty of Metallurgy at the Technical University of Kosice
Research activities are mainly focused on the study of the biochemical and biophysical properties of amyloid-prone proteins: i) anti-amyloid study - focusing on pathological amyloid aggregation connected with neurodegenerative diseases that will optimize the application of newly prepared compounds/particles in the treatment of amyloid-related diseases and enable imaging of amyloid formation/decomposition; ii) fabrication of protein superstructures by chemical appending of functional ligands onto self-assembling peptides or proteins, and iii) fabrication of protein-hydrogels - i) preparation of single(one)-type amyloid-based hydrogels; ii) fabrication of mixed protein-hydrogels by entrapping DNA-protein hybrids that could lead to the developing new materials with unprecedented structural and functional features.
Selected publications:
SHLAPA, Yuliia** - ŠIPOŠOVÁ, Katarína** - SARNATSKAYA, Veronika - DRAJNOVA, Michaela - SILVESTRE-ALBERO, Joaquin - LYKHOVA, Olexandra - MARALOUI, Valentin-Adrian - SOLOPAN, Sergii Oleksandrovich - MOLČAN, Matúš - MUSATOV, Andrey - BELOUS, Anatolii. Bioactive Carbon@CeO2 Composites as Efficient Antioxidants with Antiamyloid and Radioprotective Potentials. In ACS Applied Bio Materials, 2024, vol.7, no. 10, p. 6749-6767. (2023: 4.6 - IF, Q2 - JCR, 0.9 - SJR, Q1 - SJR). ISSN 2576-6422.
SHLAPA, Yulia** - ŠIPOŠOVÁ, Katarína - VELTRUSKA, Katerina - MARALOIU, V.A. - GARČÁROVÁ, Ivana - RAJŇÁK, Michal - MUSATOV, Andrey** - BELOUS, Anatolii. Design of Magnetic Fe3O4/CeO2 "Core/Shell"-Like Nanocomposites with Pronounced Antiamyloidogenic and Antioxidant Bioactivity. In ACS Applied Materials & Interfaces, 2023, vol. 15, no. 42, p. 49346-49361. (2022: 9.5 - IF, Q1 - JCR, 2.178 - SJR, Q1 - SJR). ISSN 1944-8244
ŠIPOŠOVÁ, Katarína** - HUNTOŠOVÁ, Veronika - SEDLÁKOVÁ, Dagmar - MÁČAJOVÁ, Mariana - BILČÍK, Boris - VENUGOPALAN NAIR, Anupama - NAIR, Sumesh - HOVHANNISYAN, Vladimir - CHEN, Shean-Jen - MUSATOV, Andrey. Biocompatible zeolite-dye composites with anti-amyloidogenic properties. In International Journal of Biological Macromolecules, 2023, vol. 251, art. no. 126331. (2022: 8.2 - IF, Q1 - JCR, 1.187 - SJR, Q1 - SJR). ISSN 0141-8130
SIPOSOVA, K. - PETRENKO, V.I. – GARCAROVA, I. - SEDLAKOVA, D. - ALMASY, L. - KYZYMA, E.A. - KRIECHBAUM, M. - MUSATOV, A. The intriguing dose-dependent effect of selected amphiphilic compounds on insulin amyloid aggregation: Focus on a cholesterol-based detergent, Chobimalt. In Frontiers in Molecular Biosciences: open access, 2022, vol. 9, art. no. 955282.
HOVHANNISYAN, Vladimir - SIPOSOVA, Katarína - MUSATOV, Andrey - CHEN, Shean-Jen. Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia. Scientific Reports, 2021, vol. 11, no. 1, art. no. 5528.
SIPOSOVA, K. - KOZAR, T. - STUPAKOVA, M. - MUSATOV, A. Complementary experimental and computational analysis of the effects of non-ionic detergents and phospholipids on insulin amyloid aggregation. In Colloids and Surfaces B - Biointerfaces, 2021, vol. 197, art. no. 111428.
SIPOSOVA, K. - PETRENKO, V.I. - IVANKOV, O.I. - MUSATOV, A. - BULAVIN, L.A. - AVDEEV, M.V. - KYZYMA, E.A. Fullerenes as an Effective Amyloid Fibrils Disaggregating Nanomaterial. In ACS Applied Materials & Interfaces, 2020, vol. 12, no. 29, p. 32410-32419.
SIPOSOVA, K. - HUNTOSOVA, V. - SHLAPA, Y. - LENKAVSKA, L. - MACAJOVA, M. - BELOUS, A. - MUSATOV, A. Advances in the Study of Cerium Oxide Nanoparticles: New Insights into Antiamyloidogenic Activity. In ACS Applied Bio Materials, 2019, vol. 2, no. 5, p. 1884-1896.
SIPOSOVA, K. - KOZAR, T. - HUNTOSOVA, V. - TOMKOVA, S. - MUSATOV, A. Inhibition of amyloid fibril formation and disassembly of pre-formed fibrils by natural polyphenol rottlerin. In Biochimica et Biophysica Acta: proteins and proteomics, 2019, vol. 1867, no. 3, p. 259-274.
• Master's degree in biochemistry received in 2009 at the P.J. Safarik University in Kosice
• PhD in biochemistry received in 2013 at the P.J. Safarik University in Kosice
• in 2017 she graduated in the field of Environmental Engineering at the Faculty of Metallurgy at the Technical University of Kosice
Research activities are mainly focused on the study of the biochemical and biophysical properties of amyloid-prone proteins: i) anti-amyloid study - focusing on pathological amyloid aggregation connected with neurodegenerative diseases that will optimize the application of newly prepared compounds/particles in the treatment of amyloid-related diseases and enable imaging of amyloid formation/decomposition; ii) fabrication of protein superstructures by chemical appending of functional ligands onto self-assembling peptides or proteins, and iii) fabrication of protein-hydrogels - i) preparation of single(one)-type amyloid-based hydrogels; ii) fabrication of mixed protein-hydrogels by entrapping DNA-protein hybrids that could lead to the developing new materials with unprecedented structural and functional features.
Selected publications:
SHLAPA, Yuliia** - ŠIPOŠOVÁ, Katarína** - SARNATSKAYA, Veronika - DRAJNOVA, Michaela - SILVESTRE-ALBERO, Joaquin - LYKHOVA, Olexandra - MARALOUI, Valentin-Adrian - SOLOPAN, Sergii Oleksandrovich - MOLČAN, Matúš - MUSATOV, Andrey - BELOUS, Anatolii. Bioactive Carbon@CeO2 Composites as Efficient Antioxidants with Antiamyloid and Radioprotective Potentials. In ACS Applied Bio Materials, 2024, vol.7, no. 10, p. 6749-6767. (2023: 4.6 - IF, Q2 - JCR, 0.9 - SJR, Q1 - SJR). ISSN 2576-6422.
SHLAPA, Yulia** - ŠIPOŠOVÁ, Katarína - VELTRUSKA, Katerina - MARALOIU, V.A. - GARČÁROVÁ, Ivana - RAJŇÁK, Michal - MUSATOV, Andrey** - BELOUS, Anatolii. Design of Magnetic Fe3O4/CeO2 "Core/Shell"-Like Nanocomposites with Pronounced Antiamyloidogenic and Antioxidant Bioactivity. In ACS Applied Materials & Interfaces, 2023, vol. 15, no. 42, p. 49346-49361. (2022: 9.5 - IF, Q1 - JCR, 2.178 - SJR, Q1 - SJR). ISSN 1944-8244
ŠIPOŠOVÁ, Katarína** - HUNTOŠOVÁ, Veronika - SEDLÁKOVÁ, Dagmar - MÁČAJOVÁ, Mariana - BILČÍK, Boris - VENUGOPALAN NAIR, Anupama - NAIR, Sumesh - HOVHANNISYAN, Vladimir - CHEN, Shean-Jen - MUSATOV, Andrey. Biocompatible zeolite-dye composites with anti-amyloidogenic properties. In International Journal of Biological Macromolecules, 2023, vol. 251, art. no. 126331. (2022: 8.2 - IF, Q1 - JCR, 1.187 - SJR, Q1 - SJR). ISSN 0141-8130
SIPOSOVA, K. - PETRENKO, V.I. – GARCAROVA, I. - SEDLAKOVA, D. - ALMASY, L. - KYZYMA, E.A. - KRIECHBAUM, M. - MUSATOV, A. The intriguing dose-dependent effect of selected amphiphilic compounds on insulin amyloid aggregation: Focus on a cholesterol-based detergent, Chobimalt. In Frontiers in Molecular Biosciences: open access, 2022, vol. 9, art. no. 955282.
HOVHANNISYAN, Vladimir - SIPOSOVA, Katarína - MUSATOV, Andrey - CHEN, Shean-Jen. Development of multifunctional nanocomposites for controlled drug delivery and hyperthermia. Scientific Reports, 2021, vol. 11, no. 1, art. no. 5528.
SIPOSOVA, K. - KOZAR, T. - STUPAKOVA, M. - MUSATOV, A. Complementary experimental and computational analysis of the effects of non-ionic detergents and phospholipids on insulin amyloid aggregation. In Colloids and Surfaces B - Biointerfaces, 2021, vol. 197, art. no. 111428.
SIPOSOVA, K. - PETRENKO, V.I. - IVANKOV, O.I. - MUSATOV, A. - BULAVIN, L.A. - AVDEEV, M.V. - KYZYMA, E.A. Fullerenes as an Effective Amyloid Fibrils Disaggregating Nanomaterial. In ACS Applied Materials & Interfaces, 2020, vol. 12, no. 29, p. 32410-32419.
SIPOSOVA, K. - HUNTOSOVA, V. - SHLAPA, Y. - LENKAVSKA, L. - MACAJOVA, M. - BELOUS, A. - MUSATOV, A. Advances in the Study of Cerium Oxide Nanoparticles: New Insights into Antiamyloidogenic Activity. In ACS Applied Bio Materials, 2019, vol. 2, no. 5, p. 1884-1896.
SIPOSOVA, K. - KOZAR, T. - HUNTOSOVA, V. - TOMKOVA, S. - MUSATOV, A. Inhibition of amyloid fibril formation and disassembly of pre-formed fibrils by natural polyphenol rottlerin. In Biochimica et Biophysica Acta: proteins and proteomics, 2019, vol. 1867, no. 3, p. 259-274.