PhD. Topics
Centre of Experimental Medicine SAS
Topic
Novel inhibitors of aldose reductase and in vitro testing of selected derivatives as potencial drugs in prevention of diabetic complications
PhD. program
Biochemistry
Year of admission
2025
Name of the supervisor
RNDr. Lucia Kováčiková, PhD.
Contact:
Receiving school
Faculty of Natural Sciences Comenius University
Annotation
Improvement of therapeutic interventions in prevention/treatment of diabetic complications and chronic inflammatory disorders represents an urgent challenge. This work comprises a multidisciplinary approach based on the knowledge of relevant molecular factors, namely the role of the polyol pathway and oxidative stress in the etiology of the mentioned pathologies, combined with medicinal chemistry approaches in drug design, including in silico modeling and virtual screening. The experimental part will focus on the development of novel pharmacologically applicable aldose reductase inhibitors endowed with high efficacy and selectivity, good bioavailability and negligible toxicity is envisaged. Moreover, the results may contribute to understanding molecular mechanisms of glucose toxicity in the etiology of diabetic complications and oxidative stress related mechanisms in chronic inflammation.