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PhD. Topics

Biomedical Research Center SAS

Topic
Development of a Lateral flow assay for Q fever
PhD. program
molecular biology
Name of the supervisor
Mgr. Gabriela Flores-Ramírez, PhD.
Contact:
Receiving school
Faculty of Natural Sciences, Comenius University in Bratislava
Annotation
Lateral flow assays (LFAs) are rapid diagnostic devices that can be used to test for a target substance (antigen) in a sample (saliva, sera or blood). Nowadays are widely use in the health and veterinary system fields. Some of the advantages to the LFA are that these assays have a long shelf life, do not require refrigerated storage, can handle small volumes of antigen and sample, can have high sensitivity, specificity and stability, it does not need extensive training for using it and it have a relative low cost for development. Coxiella burnetii causes Q fever. During the last decade, several outbreaks in Europe of the illness occurred causing both, economical losses in the livestock industry and the spread of the infection in humans. Due to their similar symptoms with commonly bacterial infections and its clinical diagnosis requires time and special methods. In here, we propose a)to study the immunoreactive secreted proteins and b) to develop an optimize a lateral flow assay for Q fever.