Centre of Experimental Medicine SAS
Role of non-coding RNAs in cardioprotective effects of selected antioxidants
Name of the supervisor
doc. RNDr. Monika Barteková, PhD.
Faculty of Natural Sciences Comenius University
Cardiovascular disease is the leading cause of mortality worldwide. Therefore, the investigation of pathological mechanisms leading to the development of cardiovascular diseases is of considerable importance in terms of the development of future cardioprotective therapies. In recent years, a significant portion of cardiovascular research has focused on the role of non-coding RNAs in the development of cardiovascular disease, and these molecules are thought to be potential targets of future therapeutic interventions. In line with this trend, the PhD. study will be intended to examine the role of selected miRNAs and lncRNAs in the pathophysiology of ischemia-reperfusion (I / R) injury of the heart and also to examine how their levels /expression are affected by the administration of cardioprotective antioxidants, such as quercetin flavonoid, aimed to elucidate the role of noncoding RNAs in I/R injury and cardioprotection targeted at oxidative damage of cardiac myocytes.