Institute of Materials and Machine Mechanics
Development of a new biomedical composite with TNTZ matrix and biodegradable component (Zn, Mg, Ca) with low modulus of elasticity and increased surface bioactivity
Advanced materials and material design
Name of the supervisor
Ing. Martin Balog, PhD.
Materiálovotechnologická fakulta STU
The aim of the doctoral thesis is the development of a new bulk composite material with Ti (TNTZ) matrix and biodegradable component (Zn, Mg, Ca) with an extremely low modulus of elasticity for the application of permanent biomedical implants subjected to intense and cyclic loading. The developed material aims to minimize the basic shortcomings of current Ti implants, namely mechanical incompatibility (so-called stress-shielding effect) and insufficient surface bioactivity. During the interdisciplinary work the doctoral student will be responsible for: i) fabrication and optimization of composite preparation technologies of powder metallurgy and hydrostatic extrusion, ii) complex microstructural characterisation, iii) optimization of TNTZ matrix chemistry and determination of biodegradable component influencing mechanical and fatigue properties, iv) determination of corrosion resistance and rate of degradation of the biodegradable component in simulated body fluids, v) in-vitro cell culture response studies, i.e., viability, proliferation, DNA degradation, oxidative stress of the optimized composite materials. The doctoral student will be required for both experimental and analytical type of research. The doctoral student will have to handle various technologies of powder metallurgy, will use the methods of thermal analysis (TGA, DSC) and electron microscopy (SEM, TEM), spectrometric methods (EBSD, EDS), X-ray diffraction (XRD), mechanical (tensile tests, DMA) and fatigue tests, at collaborative bases he/she will participate on in-vitro cell culture biological response (MTT) assays. The doctoral thesis will be supported by an applied research project and the student will work closely with the BMC SAS and other foreign institutions. A previous experience related to a given type of materials research, fluent and active knowledge of the English language, the ability to work in a dynamic team and independence are required.