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PhD. Topics

Centre of Biosciences SAS

Topic
Phosphatidylglycerol and its role in the inflammatory response
PhD. program
Biochemistry/Genetics
Name of the supervisor
Mgr. Mária Balážová, PhD.
Contact:
Receiving school
Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava
Annotation
The main objective of PhD thesis is to contribute to the knowledge about the potential use of valproic acid to induce the synthesis of phosphatidylglycerol in the pulmonary surfactant. To answer specific questions, we will use three models differing in their complexity – yeast (Saccharomyces cerevisiae), human tumor cell line (HAP1), and avian chorioallantoic membrane. We hypothesize that intracellularly increased phosphatidylglycerol level could suppress inflammatory responses in acute respiratory distress syndrome (ARDS) patients and reduce the attachment of the virus to cell surface receptors. This would mean a reduction in infectious particle transmission between individuals and significant alleviation of ARDS symptoms.