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PhD. Topics

Institute of Experimental Physics

Structural, Functional, and Dynamic Features of Protein Amyloid Structures
PhD. program
Name of the supervisor
RNDr., Ing. Katarína Šipošová, PhD.
Receiving school
Faculty of Science, P.J. Safarik University
Proteins are important biological macromolecules that are fundamental to the proper functioning of cells and organisms. Loss of protein homeostasis is a common feature of aging and disease that is characterized by the appearance of nonnative protein aggregates in various tissues. There are several hypotheses on how amyloid fibrils form and understanding how amyloid fibrillization can be modulated is undoubtedly very important.
The doctoral research will focus on proving or disproving one of the generally accepted hypotheses - oxidative stress-induced aggregation of protein amyloid. During the doctoral dissertation, a study of the structural and functional consequences of the interaction
of protein/protein amyloid structures with various types of substances, including multifunctional composites, will be conducted. The second goal will be the preparation of multifunctional composites, which can be used: i) as the promising (biocompatible) carriers for targeted drug delivery with controllable release, and ii) in future experiments for direct monitoring of anti-amyloid activity.