Polymer Institute
Biopolymers for the development of innovative treatments and energy self-sufficiency
Využitie biopolymérov pre vývoj inovatívnych liečebných postupov a energetickej sebestačnosti.
Activation of the VGF/BDNF/TrkB pathway by synthetic mRNA encapsulated in polyplex nanoparticles: effects on neural excitability, neuroplasticity and animal behaviour.
Aktivácia VGF/BDNF/TrkB dráhy syntetickou mRNA zapúzdrenou v polyplexových nanočasticiach: účinky na nervovú excitabilitu, neuroplasticitu a správanie zvierat.
Carbon-silicon based composite anodes for Li-ion batteries
ALICES: Anódy pre Li-iónové batérie na báze uhlík-kremíkových kompozitov
Bionanocomposites based on organic polycations and layered silicates
BioPolSil: Bionanokompozitné materiály na báze vrstevnatých silikátov
Two-dimensional nanomaterials in hybrids and polymer composites for advanced applications
Dvojdimenzionálne nanomateriály v hybridoch a polymérnych kompozitoch pre pokročilé aplikácie
Immobilization and co-immobilization of viable whole-cell biocatalysts with enzyme cascades for production of chemical specialties, development of methods for their characterization and bioreactor engineering.
Imobilizácia a koimobilizácia viabilných celobunkových biokatalyzátorov s enzýmovými kaskádami pre produkciu chemických špecialít, vývoj metód ich charakterizácie a bioreaktorové inžinierstvo.
In situ reduction of graphene oxide assisted by polymer chains: computational and experimental study.
In situ redukcia grafén oxidu asistovaná polymérnymi reťazcami: výpočtová a experimentálna štúdia.
Injectable shear-thinning polymeric hydrogels by supramolecular and dynamic covalent networks for cartilage tissue regeneration.
Injektovateľné pseudoplastické polymérne hydrogély založené na supramolekulárnych a dynamických kovalentných sieťach pre regeneráciu chrupavkového tkaniva.
Duration: |
1.6.2023 - 30.6.2027 |
Program: |
SRDA |
Project leader: |
Heydari Abolfazl PhD. |
Annotation: | The goal of this project is to develop tissue-engineered articular cartilage using an injectable shear-thinning hydrogel administered in a minimally invasive way into living bodies, with the ability to match irregular defects and fulfill most of the requirements for cartilage regeneration. This hydrogel will be formed based on bioorthogonal chemistry through the combination of both dynamic supramolecular and covalent crosslinks. The intention is to improve the mechanical properties to mimic the extracellular matrix (ECM) of articular cartilage without compromising the biocompatibility of the hydrogel. Simultaneously, the hydrogel composition will be modulated to meet the fundamental requirements of the scaffold in treating cartilage, including (i) bioadhesion, (ii) promotion of chondrogenesis, and (iii) biodegradation without toxic by-products. The performance of the proposed platform will be tested in a rabbit model for cartilage regeneration.
Dosiahnuté výsledky: Throughout this year, our main focus was on different aspects of polymer library preparation. We synthesized the essential polymer library crucial for the development of injectable hydrogels. As an initial experiment, we devised and created crosslinked injectable hydrogels utilizing both non-covalent and covalent bonds. We assessed the impact of covalent bonds, particularly hydrazone bonds, on the properties of the injected hydrogel, including its chemical and mechanical stability.
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Konštrukcia inteligentných polymérnych kompozitných systémov pre kontrolované a cielené podávanie liečiv.
Duration: |
1.12.2022 - 30.9.2025 |
Program: |
SASPRO |
Project leader: |
Assoc. Prof. Omer Ahmed Mohamed PhD. |
Annotation: | The overall objective of this project is to develop and evaluate new smart bioactive composites for controlled and targeted drug delivery. These systems will be constructed in forms of bioactive hydrogel Nanocomposites based on modified natural polymers and bioactive MOFs materials. It is expected that the presence of biopolymer derivatives not only leads to the biodegradability and biocompatibility of the system but also leads to the release of anticancer drugs to a greater extent at pH. In addition, functionalization of biopolymer with an extra amine and carboxylic groups is expected to provide stimuli responsive character for the constructed bionanocomposite carrier. Additionally, these platforms will be fabricated in form of duel layered core-shell hydrogel composites microcapsules through polyelectrolyte complex formation based on maodified natural polymers in combination with bioactive Graphene Oxide derivative. These polyelectrolyte complexes are expected to custimize the targeted and controlled drug release profiles. Finally, it is aimed also to construct grafted biocomposie hydrogels based on β-cyclodextrin grafted biopolymer and MOFs and/or GO-derivatives materials as smart pH-sensitive drug carriers. |
Alginate-based microcapsules with enhanced stability and biocompatibility for encapsulation of pancreatic islets in diabetes treatment.
Mikrokapsuly na báze alginátu so zvýšenou stabilitou a biokompatibilitou pre enkapsuláciu pankreatických ostrovčekov v liečbe cukrovky.
Modification of surfaces as barrier to protein adsorption.
Modifikácia povrchov ako bariéra pre adsorpciu proteínov.
Advanced Oxygen Tolerant Photochemically Induced Atom Transfer Radical Polymerization.
Pokročilá fotochemicky indukovaná radikálová polymerizácia s prenosom atómu tolerantná k prítomnosti kyslíka.
Towards Superior Perovskite-based Solar Cells via Optimized Passivation and Structure.
Pokročilé perovskitové solárne články s optimalizovanou pasiváciou a štruktúrou.
Polymers and polymeric materials with added value from renewable resources.
Polyméry a polymérne materiály s pridanou hodnotou z obnoviteľných zdrojov.
Self-healing implantable polymeric microspheres crosslinked via bioorthogonal click chemistry for cell encapsulation in diabetes treatment.
Samoregeneračné implantovateľné polymérne mikrosféry sieťované prostredníctvom bioortogonálnej klik chémie pre bunkovú enkapsuláciu v liečbe cukrovky.
Duration: |
1.1.2023 - 31.12.2025 |
Program: |
VEGA |
Project leader: |
Heydari Abolfazl PhD. |
Annotation: | The goal of the project is to develop biocompatible alginate-based microspheres stabilized by dual ionic and dynamic covalent crosslinks with self-healing characteristics. The intention is to enhance the chemical and mechanical durability of the microspheres by incorporating dynamic bonds into their network and mitigating foreign body responses using anti-fibrotic agents located on the microsphere surface. These crucial features of microspheres will be tuned through alterations in the alginate backbone by introducing various contents of bio-clickable and anti-fibrotic agents. |
System program for complex knowledge and critical thinking in the experiential education form.
Systémový program pre komplexné poznávanie a kritické myslenie formou zážitkového vzdelávania.
The influence of varying humidity conditions on the structure and mechanical properties of thermoplastic starch-based materials.
Vplyv meniacich sa vlhkostných podmienok na štruktúru a mechanické vlastnosti termoplastických materiálov na báze škrobu.
Influence of supramolecular structure on ultimate properties of blends of biodegradable polymers with thermoplastic starch
Vplyv nadmolekulovej štruktúry na úžitkové vlastnosti zmesí biodegradovateľných polymérov s termoplastickým škrobom
The effect of solvent composition on kinetics and mechanism of radical polymerization for water-soluble monomers.
Vplyv zloženia rozpúšťadla na kinetiku a mechanizmus radikálovej polymerizácie vodorozpustných monomérov.
The occurence of microplastics and selected micropollutants in surface and drinking waters of Slovakia and their effective removal by progressive processes.
Výskyt mikroplastov a vybraných mikropolutantov v povrchových a pitných vodách Slovenska a ich účinné odstránenie pomocou progresívnych postupov.
Changes of microstructure and physical properties of crosslinked polymers in bulk and under confined conditions of macro- and mesopores.
Zmeny mikroštruktúry a fyzikálnych vlastností zosieťovaných polymérov v objeme a uväznených podmienkach makro- a mezo-pórov.
The total number of projects: 21