In: General Physiology and Biophysics, vol. 32, no. 2
Katarina Siposova - Eva Bystrenova - Andrea Antosova - Martina Koneracka - Vlasta Zavisova - Peter Kopcansky - Zuzana Gazova
Detaily:
Rok, strany: 2013, 209 - 214
O článku:
Presence of protein amyloid deposits is associated with pathogenesis of amyloid-related diseases. Insulin amyloid aggregates have been reported in a patient with diabetes undergoing treatment by injection of insulin. We have investigated the interference of insulin amyloid aggregation with two Fe3O4-based magnetic fluids. The magnetic fluids are able to inhibit insulin amyloid fibrillization and promote disassembly of amyloid fibrils. The cytotoxic effect of amyloid fibrils is attenuated in presence of magnetic fluids probably due to reduction of the fibrils. We suggest that present findings propose the potential use of Fe3O4-based magnetic fluids as the therapeutic agents targeting insulin-associating amyloidosis.
Ako citovať:
ISO 690:
Siposova, K., Bystrenova, E., Antosova, A., Koneracka, M., Zavisova, V., Kopcansky, P., Gazova, Z. 2013. Attenuation of the insulin amyloid aggregation in presence of Fe3O4-based magnetic fluids. In General Physiology and Biophysics, vol. 32, no.2, pp. 209-214. 0231-5882.
APA:
Siposova, K., Bystrenova, E., Antosova, A., Koneracka, M., Zavisova, V., Kopcansky, P., Gazova, Z. (2013). Attenuation of the insulin amyloid aggregation in presence of Fe3O4-based magnetic fluids. General Physiology and Biophysics, 32(2), 209-214. 0231-5882.