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Serum lipoprotein composition, lecithin cholesterol acyltransferase and tissue lipase activities in pregnant diabetic rats and their offspring receiving enriched n-3 PUFA diet

In: General Physiology and Biophysics, vol. 27, no. 1
N. Soulimane-Mokhtari - B. Guermouche - M. Saker - S. Merzouk - H. Merzouk - A. Hichami - S. Madani - N. Khan - J. Prost
Detaily:
Rok, strany: 2008, 3 - 11
O článku:
The effects of dietary n-3 polyunsaturated fatty acids on lipoprotein concentrations and on lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL) and lecithin cholesterol acyltransferase (LCAT) activities were studied in streptozotocin-induced diabetic rats during pregnancy and in their macrosomic offspring from birth to adulthood. Pregnant diabetic and control rats were fed Isio-4 diet (vegetable oil) or EPAX diet (concentrated marine omega-3 EPA/DHA oil), the same diets were consumed by pups at weaning. Compared with control rats, diabetic rats showed, during pregnancy, a significant elevation in very low density lipoprotein (VLDL) and low and high density lipoprotein (LDL-HDL1)-triglyceride, cholesterol and apoprotein B100 concentrations and a reduction in apoprotein A-I levels. HTGL activity was high while LPL and LCAT activities were low in these rats. The macrosomic pups of Isio-4-fed diabetic rats showed a significant enhancement in triglyceride and cholesterol levels at birth and during adulthood with a concomitant increase in lipase and LCAT activities. EPAX diet induces a significant diminution of VLDL and LDL-HDL1 in mothers and in their macrosomic pups, accompanied by an increase in cholesterol and apoprotein A-I levels in HDL2–3 fraction. It also restores LPL, HTGL and LCAT activities to normal range. EPAX diet ameliorates considerably lipoprotein disorders in diabetic mothers and in their macrosomic offspring.
Ako citovať:
ISO 690:
Soulimane-Mokhtari, N., Guermouche, B., Saker, M., Merzouk, S., Merzouk, H., Hichami, A., Madani, S., Khan, N., Prost, J. 2008. Serum lipoprotein composition, lecithin cholesterol acyltransferase and tissue lipase activities in pregnant diabetic rats and their offspring receiving enriched n-3 PUFA diet. In General Physiology and Biophysics, vol. 27, no.1, pp. 3-11. 0231-5882.

APA:
Soulimane-Mokhtari, N., Guermouche, B., Saker, M., Merzouk, S., Merzouk, H., Hichami, A., Madani, S., Khan, N., Prost, J. (2008). Serum lipoprotein composition, lecithin cholesterol acyltransferase and tissue lipase activities in pregnant diabetic rats and their offspring receiving enriched n-3 PUFA diet. General Physiology and Biophysics, 27(1), 3-11. 0231-5882.