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Morphofunctional characteristics of ACTH cells in middle-aged male rats after treatment with genistein

In: General Physiology and Biophysics, vol. 28, no. 1
Verica Milošević - Vladimir Ajdžanović - Branka Šošić-Jurjević - Branko Filipović - Marjana Brkić - Nataša Nestorović - Milka Sekulić
Detaily:
Rok, strany: 2009, 94 - 97
O článku:
The soybean phytoestrogen, genistein, is increasingly consumed as an alternative therapeutic for age-related diseases. The aim of this study was to examine the morphofunctional characteristics of adrenocorticotrophic (ACTH) cells and blood concentrations of ACTH in sham-operated, orchidectomized and genistein-treated orchidectomized, 16-month-old Wistar male rats. Genistein (10 mg/kg/day) was administered subcutaneously for three weeks, while the control groups received the vehicle alone. Orchidectomy and genistein treatment decreased the volume density of ACTH cells and reduced (p < 0.05) circulating ACTH concentrations in comparison with control groups. In conclusion, genistein modulated the morphofunctional features of ACTH cells and decreased blood ACTH levels.
Ako citovať:
ISO 690:
Milošević, V., Ajdžanović, V., Šošić-Jurjević, B., Filipović, B., Brkić, M., Nestorović, N., Sekulić, M. 2009. Morphofunctional characteristics of ACTH cells in middle-aged male rats after treatment with genistein. In General Physiology and Biophysics, vol. 28, no.1, pp. 94-97. 0231-5882.

APA:
Milošević, V., Ajdžanović, V., Šošić-Jurjević, B., Filipović, B., Brkić, M., Nestorović, N., Sekulić, M. (2009). Morphofunctional characteristics of ACTH cells in middle-aged male rats after treatment with genistein. General Physiology and Biophysics, 28(1), 94-97. 0231-5882.