A possible role of NF‐κB and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats

Rok, strany: 2010, 234 - 242

Effects of heat stress on phosphorylated nuclear factor‐κB (phospho‐NF‐κB) and tumor necrosis factor α (TNFα) contents in skeletal muscles were studied. Male Wistar rats (7‐week‐old) were randomly assigned to control and heat‐stressed groups. Rats in heat‐stressed group were exposed to heat stress (42°C for 60 min) in an incubator without anesthesia. Soleus muscles were dissected and weighted 1, 3, and 7 days after the heat exposure. Significant increases in the wet weight and protein content of soleus were observed 7 days following the exposure (p < 0.05). Heat stress also induced the up‐regulation of heat shock protein 72 (HSP72), IκBα (inhibitor of NF‐κB) and the increase in the relative population of Pax7‐positive satellite cells to total muscle nuclei before the increase in muscle mass. The content levels of phospho‐NF‐κB and TNFα were significantly decreased 1 and 3 days after heat stress, respectively (p < 0.05). A negative correlation between HSP72 and phospho‐NF‐κB contents was observed 1 day after the heat exposure. These observations suggest that the decrease in NF‐κB signaling may play a part of a role in heat stress‐associated muscle hypertrophy.

ISO 690:

Ohno, Y., Yamada, S., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K. 2010. A possible role of NF‐κB and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats. In General Physiology and Biophysics, vol. 29, no.3, pp. 234-242. 0231-5882.

APA:

Ohno, Y., Yamada, S., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K. (2010). A possible role of NF‐κB and HSP72 in skeletal muscle hypertrophy induced by heat stress in rats. General Physiology and Biophysics, 29(3), 234-242. 0231-5882.