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Expressional changes of RyR1 and RyR2 in PC12 cells after induction of apoptosis

In: General Physiology and Biophysics, vol. 29, no. 4
Dana Jurkovicova - Lubomira Lencesova - Olga Krizanova
Detaily:
Rok, strany: 2010, 414 - 418
O článku:
Ca2+ released from endoplasmic reticulum through ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) can trigger apoptotic or necrotic pathways in cooperation with proapoptotic and/or prosurvival proteins, as those of Bcl-2 family. In such regulatory pathways expressional modulation of these Ca2+ transporters could also be expected. Therefore, our aim was to determine the expressional changes of RyR1 and RyR2 after experimental induction of apoptosis in PC12 cells. Our results showed significant decrease of RyR1 and RyR2 expressions, while caspase-3 and Bax expression significantly increased. We conclude that induction of apoptosis in PC12 cells could result in RyR expression down regulation.
Ako citovať:
ISO 690:
Jurkovicova, D., Lencesova, L., Krizanova, O. 2010. Expressional changes of RyR1 and RyR2 in PC12 cells after induction of apoptosis. In General Physiology and Biophysics, vol. 29, no.4, pp. 414-418. 0231-5882.

APA:
Jurkovicova, D., Lencesova, L., Krizanova, O. (2010). Expressional changes of RyR1 and RyR2 in PC12 cells after induction of apoptosis. General Physiology and Biophysics, 29(4), 414-418. 0231-5882.