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NGF-induced neurite outgrowth in PC12 cells is independent of calcium entry through L-type calcium channels

In: General Physiology and Biophysics, vol. 31, no. 4
Lucia Lichvárová - Katarína Jašková - Ľubica Lacinová
Detaily:
Rok, strany: 2012, 473 - 478
O článku:
Neuronal growth factor (NGF) induces neurodifferentiation of PC12 cells into cholinergic neurons-like cells. It was shown that intracellular Ca2+ ions participate in regulation of the differentiation of PC12 cells. We tested whether L-type calcium channels contribute to Ca2+ entry which supports neurite outgrowth accompanying NGF-activated differentiation process. Development of morphological changes did correlate with increase of functional expression of L-type calcium channels. However, inhibition of L-type calcium channels by 1 μM of isradipine did not affect significantly an NGF-activated neurite outgrowth.
Ako citovať:
ISO 690:
Lichvárová, L., Jašková, K., Lacinová, Ľ. 2012. NGF-induced neurite outgrowth in PC12 cells is independent of calcium entry through L-type calcium channels. In General Physiology and Biophysics, vol. 31, no.4, pp. 473-478. 0231-5882.

APA:
Lichvárová, L., Jašková, K., Lacinová, Ľ. (2012). NGF-induced neurite outgrowth in PC12 cells is independent of calcium entry through L-type calcium channels. General Physiology and Biophysics, 31(4), 473-478. 0231-5882.