Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions: Testing of stobadine and its two derivatives in function as antioxidants

Rok, strany: 2012, 57 - 64

Stobadine·2HCl and its two hydrophilic derivatives SM1dM9dM10·2HCl and SME1i-ProC2·HCl were tested in the function of antioxidants on hyaluronan (HA) degradation induced by the Weissberger oxidative system [ascorbate plus Cu(II)]. As a primary method, rotational viscometry was applied, where the substance tested was added before or 1 h after the initiation of HA degradation. The most effective scavengers of •OH and peroxy-type radicals were recorded to be stobadine·2HCl and SME1i-ProC2·HCl, respectively. The most effective scavenger, determined by applying the ABTS assay, was stobadine·2HCl.

ISO 690:

Surovcikova-Machova, L., Valachova, K., Banasova, M., Snirc, V., Priesolova, E., Nagy, M., Juranek, I., Soltes, L. 2012. Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions: Testing of stobadine and its two derivatives in function as antioxidants. In General Physiology and Biophysics, vol. 31, no.1, pp. 57-64. 0231-5882.

APA:

Surovcikova-Machova, L., Valachova, K., Banasova, M., Snirc, V., Priesolova, E., Nagy, M., Juranek, I., Soltes, L. (2012). Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions: Testing of stobadine and its two derivatives in function as antioxidants. General Physiology and Biophysics, 31(1), 57-64. 0231-5882.