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Lymph node mapping using quantum dot-labeled polymersomes

In: General Physiology and Biophysics, vol. 34, no. 4
Rumiana Bakalova - Zhivko Zhelev - Biliana Nikolova - Shuhei Murayama - Desislava Lazarova - Iana Tsoneva - Ichio Aoki
Detaily:
Rok, strany: 2015, 393 - 398
O článku:
The present study was designed to investigate whether poly-ion complex hollow vesicles (polymersomes), based on chemically-modified chitosan, are appropriate for lymph node mapping in the context of their application in the development of theranostic nanosized drug delivery systems (nano-DDS). The experiments were performed on Balb/c nude mice (colon cancer-grafted). The mice were subjected to anesthesia and quantum dot (QD705)-labeled polymersomes (d~120 nm) were injected intravenously via the tail vein. The optical imaging was carried out on Maestro EX Imaging System (excitation filter: 435–480 nm; emission filter: 700 nm). A strong fluorescent signal, corresponding to QD705 fluorescence, was detected in the lymph nodes, as well as in the tumor. A very weak fluorescent signal was found in the liver area. The half-life of QD705-labelled polymersomes was 6 ± 2 hours in the bloodstream and 11 ± 3 hours in the lymph nodes. The data suggest that polymersomes are very promising carriers for lymph node mapping using QD as a contrast agent. They are useful matrix for development of nano-formulations with theranostic capabilities.
Ako citovať:
ISO 690:
Bakalova, R., Zhelev, Z., Nikolova, B., Murayama, S., Lazarova, D., Tsoneva, I., Aoki, I. 2015. Lymph node mapping using quantum dot-labeled polymersomes. In General Physiology and Biophysics, vol. 34, no.4, pp. 393-398. 0231-5882.

APA:
Bakalova, R., Zhelev, Z., Nikolova, B., Murayama, S., Lazarova, D., Tsoneva, I., Aoki, I. (2015). Lymph node mapping using quantum dot-labeled polymersomes. General Physiology and Biophysics, 34(4), 393-398. 0231-5882.