Information Page of SAS Organisation

Institute of Experimental Physics

International projects

Amyloid aggregation of proteins in hybrid interfaces
Amyloidná agregácia proteínov na hybridných povrchoch
Program: Medziakademická dohoda (MAD)
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:The aim of the project is a study of the mechanism of aggregation of the different amyloid proteins induced by interaction with various surfaces. The main focus will be concern on the characterization of protein aggregation induced by protein interaction with solid interfaces with various geometrical as well as the chemical properties of the surfaces. We will investigate the role of the surface forces and dimensionality of nanoparticles as agents that accelerate or prevent amyloid fibrillization of proteins. Moreover, effect of the interface polarity, substrate roughness or geometrical constraints will be examined. We will compare the morphological properties of amyloid aggregates formed in solution and at solid interface.
Duration: 11.1.2016 - 31.12.2017

ALICE experiment at the CERN LHC: The study of strongly interacting matter under extreme conditions
Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach
Program: CERN/MŠ
Project leader: RNDr. Králik Ivan CSc.
Annotation:The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties.
Project web page:http://osf.saske.sk/sk/?id=vyskum&sub=experimenty_ALICE
Duration: 1.1.2016 - 31.12.2020

ATLASKE - ATLAS experiment on LHC in CERN: deep-inelastic events and new physics at TeV energies
Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách
Program: CERN/MŠ
Project leader: Doc. RNDr. Bruncko Dušan CSc.
Duration: 1.1.2016 - 31.12.2020

JEM-EUSO - JEM-EUSO, Extreme Universe Space Observatory Onboard Japan Experiment Module
JEM-EUSO, Kozmické Observatórium Extrémneho Vesmíru na palube Japonského Experimentálneho Modulu
Program: Multilaterálne - iné
Project leader: RNDr. Bobík Pavol PhD
Annotation:Research of extreme energy cosmic rays with use of observations of secondary responses in the atmosphere of Earth from the International space station
Project web page:http://jemeuso.riken.jp/en/index.html
Duration: 1.1.2010 - 31.12.2017

Magnetic properties of tetraborides
Magnetické vlastnosti tetraboridov
Program: Bilaterálne - iné
Project leader: Doc. RNDr. Flachbart Karol DrSc.
Duration: 0.0.0000 - 31.12.2017

RADIOMAG - Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy
Multifunkcionalizované nanočastice pre magnetickú hypertermiu a nepriamu radiačnú
Program: COST
Project leader: Doc. RNDr. Kopčanský Peter CSc.
Annotation:The Action aims to bring together and to organise the research outcomes from the different participating network members in a practical way to provide clinicians with the necessary input to trial a novel anti-cancer treatment combining magnetic hyperthermia and radiotherapy, also identifying future research objectives upon appraisal of the obtained results. Feedback between the different working groups here is essential, and is expected that the lifetime of this Action proposal will eventually result in a compendium of best practices for magnetic hyperthermia.RADIOMAG will generate new and strengthen the existing synergies between technical advances (thermal imaging / MH), new treatment concepts (combined targeting radiosensitisation and magnetic thermotherapy) and biocompatible coating in order to achieve a breakthrough in the clinical application of magnetic hyperthermia. Due to the complexity of this aim, synergies can only be achieved on a longer time frame, by means of workshops, STSMs, joint publications, common Horizon 2020 research proposals and exchange with other COST Actions (e.g. TD1004, TD1205).
Project web page:http://www.cost-radiomag.eu/
Duration: 13.11.2014 - 12.11.2018

NGP-NET - Non-globular proteins - from sequence to structure, function and application in molecular physiopathology
Neglobulárne proteíny - od sekvencie ku štruktúre, funkcii a aplikácii v molekulárnej fyziopatológii
Program: COST
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Non-globular proteins (NGPs) encompass different molecular phenomena that defy the traditional sequence-structure-function paradigm. NGPs include intrinsically disordered regions, tandem repeats, aggregating domains, low-complexity sequences and transmembrane domains. Although growing evidence suggests that NGPs are central to many human diseases, functional annotation is very limited. It was recently estimated that close to 40 of all residues in the human proteome lack functional annotation and many of these are NGPs. While a better understanding of NGPs is crucial to fully comprehend human molecular physiopathology, progress has been hampered so far by the lack of a systematic approach to their study.This Action Proposal aims to create a pan-European scientific network of groups that work on NGPs to strengthen, focus and coordinate research in this field. It proposes to develop a novel classification of NGPs by consensus among interested experts that will be showcased on a newly developed web site, along with meetings, training schools and scientific missions on NGP-related topics.
Project web page:http://www.cost.eu/COST_Actions/bmbs/BM1405
Duration: 27.7.2015 - 25.3.2019

NANOUPTAKE - Overcoming Barriers to Nanofluids Market Uptake ( NANOUPTAKE)
Prekonanie bariiér pre komerčné využitie nanokvapalín (NANOUPTAKE)
Program: COST
Project leader: RNDr. Timko Milan CSc.
Annotation:Nanofluids are defined as fluids that contain nanometre-sized particles with enhanced heat transfer properties. Nanofluids improve the efficiency of heat exchange and thermal energy storage. In addition, nanofluids fall within one of the Key Enabling Technologies (KET) supported by the European Commission. Although some nanofluid commercial applications currently exist, most of the current nanofluids are at Technological Readiness Levels (TRL) 1 to 3. Most of the nanofluids research in COST countries has been conducted by Research, Development and Innovation (R+D+i) centres through national funding. Additional coordinated research and development efforts are required to develop nanofluids up to higher TRL levels and to overcome commercial application barriers. If these barriers are overcome, nanofluids will be an important player in the Value Added Materials (VAM) for the energy sector.The objective of the NANOUPTAKE COST Action is to create a Europe-wide network of leading R+D+i institutions, and of key industries, to develop and foster the use of nanofluids as advanced heat transfer/thermal storage materials to increase the efficiency of heat exchange and storage systems.
Project web page:http://www.cost.eu/COST_Actions/ca/CA15119
Duration: 19.4.2016 - 18.4.2020

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Radiačné polia v blízkosti Zeme: možné súvislosti s kozmickým žiarením meraným na zemskom povrchu
Program: Medziakademická dohoda (MAD)
Project leader: Prof. Ing. Kudela Karel DrSc.
Duration: 1.1.2015 - 31.12.2017

Spectroscopic, transport and thermodynamic properties of strongly-correlated electronic systems with competing orders
Spektroskopické, transportné a termodynamické vlastnosti silno korelovaných elektrónových systémov s konkurenčnými parametrami usporiadania
Program: Medziakademická dohoda (MAD)
Project leader: RNDr. Vargaeštoková Zuzana PhD
Duration: 1.1.2015 - 31.12.2017

One pixel - Feasibility study to observe ionospheric disturbances by one pixel UV detector
Štúdia vykonateľnosti pre pozorovania ionosférických narušení jednopixelovým UV detektorom
Program: European Space Agency (ESA)
Project leader: RNDr. Bobík Pavol PhD
Annotation:First call for outline proposals under the plan for European cooperating states (PECS) in Slovakia
Duration: 1.6.2016 - 31.10.2017

- - Study of the protein amyloid aggregation in vitro and in cerebrospinal fluid
Štúdium amyloidnej agregácie proteínov in vitro a v mozgomiešnom moku
Program: Medziústavná dohoda
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Study of the amyloid aggregation of the protein in vitro and in the samples of the cerebrospinal fluid of the peoples with amyloid-related disease which obtain protein aggregation in vivo.Test of the assay for cerebrospinal fluid of the dementic and non-dementic peoples.
Duration: 13.7.2015 - 31.12.2020

Comprehensive studies of novel magnetic materials
Štúdium nových magnetických materiálov
Program: Medziakademická dohoda (MAD)
Project leader: RNDr. Zentková Mária CSc.
Duration: 1.1.2016 - 1.1.2018

Effect of small molecules and nanoparticles on amyloid aggregation of poly/peptides
Účinok malých molekúl a nanočastíc na amyloidnú agregáciu poly/peptidov
Program: Bilaterálne - iné
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:This project is aimed at examining the self-assembly of proteins into amyloid aggregates, one of the hallmarks of AD and other amyloidosis. Accordingly, there is a considerable world-wide interest to identify molecular entities that can influence the amyloid aggregation in order to facilitate the drug development for amyloid diseases. The main goals of the project are to estimate the conditions required for promoting protein misfolding, to determine the cytotoxicity of amyloid aggregates, and to identify the compounds (e.g. small molecules and nanoparticles) that are able to inhibit protein aggregation using in vitro and in silico methods. The bilateral collaboration will allow to combine expertise and experience of both partners in the field of protein aggregation and acquire complex data with aid of complementary approaches, leading to a better understanding of amyloid aggregation mechanisms. The use of equipment provided by both institutions will offer a solid background for team members in order to publish their results at conferences and in journals. Moreover, this collaborative research partnership will present an excellent opportunity for both teams’ young members to learn new techniques in the well-equipped laboratories at NTU and SAS and work as an international scientific research group.
Duration: 11.1.2016 - 31.12.2018

ChinherbAD - The multitarget low molecular compounds from traditional Chinese herbs in treatment of Alzheimer´s disease
Využitie multitargetových nízkomolekulových látok z tradičných čínskych bylín pri liečbe Alzheimerovej choroby
Program: Bilaterálne - iné
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Alzheimer's disease (AD) is a devastating neurodegenerative disorder of multifactorial nature characterized by neuroinflammation, decreasing the level of the neurotransmitter acetylcholine as well as formation of amyloid Abeta peptide plaques and neurofibrillary tangles containing abnormally posttranslationally modified tau protein. There is no effective treatment for AD so far and none of the clinically tested drugs have any feasibility to stop, substantially delay or reverse the progressive consequences of this disease. Accordingly, there is a considerable world-wide interest to facilitate the drug development for AD. Recently, the strategy of using the multi-targeted ligands seems to be the most attractive for developing effective therapy for Alzheimer´s disease due to ability of these compounds interacts with multiple targets responsible for the disease pathogenesis. The main goal of this project is to investigate multi-target responsibility of compounds including extracts from traditional Chinese herbs as potential therapeutic agents for AD. Using in vitro, in vivo and in silico methods we will study ability of these compounds to affect the neuroinflammation, to inhibit acetylcholinesterase activity, and amyloid aggregation of Abeta peptide. The bilateral collaboration will allow the both research groups to combine their expertise and experience in the field of pathology of Alzheimer´s disease. The complementary approach allows obtain more complex data leading to suggestion of possible alternatives of therapy against this devastating disease. Moreover, the project will also enable mutual utilization of equipment provided by both institutions. At the same time the young members of project's team will have the opportunity to learn new techniques in well-equipped laboratories at SAS and East China University of Science and Technology and also work in the international scientific team.
Duration: 1.1.2016 - 31.12.2017


National projects

ANMAGEL - Anisotropy of magnetoelectric coupling in rare-earth
Anizotropia magneticko - elektrickej väzby v manganitoch vzácnych zemín
Program: APVV
Project leader: RNDr. Mihalik Marián CSc.
Annotation:Magnetoelectric multiferroics are compounds wherein beyond coexistence of long-range magnetic and electric polar orders, magnetic and polar degrees of freedom are intrinsically coupled. Best examples are rare-earth manganites, whose magnetoelectric effect is associated with the competition between AFM and FM exchanges. Their magnetoelectric coupling has been frequently studied, though its origin is not fully understood, like its strong anisotropic nature. To better understand this issue, TbMn0.08Fe0.02O3, and DyMn0.08Fe0.02O3 single crystals will be grown and studied. Iron substitution of manganese already at low concentrations is known to enhance the magnetoelectric coupling. Since iron, contrarily to manganese, is magnetically isotropic, novel effects in magnetoelectric anisotropy are expected to occur. To unravel the nature of such effects, a study of structure, lattice dynamic, magnetic, thermal and ferroelectric properties will be carried out as a function of temperature for different magnetic field directions with respect to crystallographic directions.
Duration: 1.1.2016 - 31.12.2017

ANGSTROM - Atomic structure and exceptional properties of intermetallics, amorphous, nanocrystalline and complex metallic alloys
Atomárna štruktúra a unikátne vlastnosti intermetalík, amorfných, nanokryštalických a komplexných kovových zliatin
Program: APVV
Project leader: RNDr. Škorvánek Ivan CSc.
Duration: 1.7.2016 - 31.12.2019

MACOMA - Design of the structure and the functional properties of soft magnetic 3-d transitions metals based composites
Dizajn štruktúry a funkčných vlastností magneticky mäkkých kompozitných materiálov na báze 3-d prechodných kovov
Program: APVV
Project leader: RNDr. Baťková Marianna PhD.
Annotation:The project focuses on structure and functional properties design of 3-d transition metals based soft magnetic composite materials, in which will be carried out the experimental research of functional properties of advanced materials with heterogeneous structure consisting of isolated ferromagnetic particles. Magnetic micro- and nanocomposite systems will be prepared using advanced powder metallurgy method and current chemical processes. The research will be focused on explanation of the interface influence on the electric, magnetic and mechanical properties investigated magnetic composite materials. Expected results extend the potential for application of advanced soft magnetic materials suitable for use in a medium frequencies, where ferrites are currently used.
Duration: 1.7.2016 - 31.12.2019

GONanoplatform - Graphene-based nanoplatform for detection of cancer
Grafénová nanoplatforma na detekciu rakoviny
Program: APVV
Project leader: Ing. Koneracká Martina CSc.
Annotation:This project proposal reflects current technological progress and new opportunities in biomedical applications of graphene-based sensors. Our main goals include the design and development of a graphene oxide multifunctional nanoplatform (GO-MFN) for the detection of tumor cells. In the first step, the development of graphene oxide nanoflakes of appropriate size functionalized by monoclonal antibody is planned. For sensing the tumor cells, GO-MFN of 100 nm size able to interact with a single cell will be prepared. Magnetic nanoparticles added to GO-MFN will enable the inspection of deep tissues by nuclear magnetic resonance. The degree of oxidation of GO, type of the functional groups, optimal functionalization with covalently bound monoclonal antibodies and magnetic nanoparticles, are the most important technological steps. The analysis of the basic interactions related to tumor sensing will be conducted in vitro on 2D and 3D cell models up to the proof-of-principle stage that will be directly applicable to laboratory and preclinical testing. The GO-MFN interaction with the cell membrane and with the cell interior will be analysed with subcellular resolution. Such an approach will bring original knowledge and a detailed understanding of the tumor sensing process that is important for the optimization of the sensor sensitivity. Detection of biomolecules bound to GO-MFN will be addressed in real time by several techniques. The project is based on a complex multidisciplinary approach, ranging from physics and chemistry up to biomedicine and combining excellent science and the most sophisticated nano and bio-engineering. The involved partners possess key skills, infrastructure, antibodies and tumor models, and are highly motivated to reach the project goals.
Duration: 1.7.2015 - 30.6.2019

Interaction of magnetic fluids with electromagnetic field
Interakcia magnetických kvapalín s elektromagnetickým poľom
Program: VEGA
Project leader: RNDr. Timko Milan CSc.
Annotation:The proposed project will be devoted to the study magnetic principle of heating mechanism – hyperthermia in magnetic nanoparticles systems in dependence on preparation process, size and size distribution and magnetic properties. Besides usually used biocompatible spherical anoparticles as a subjects of this proposal will be special prepared magnetosome and magnetoferritin containing spherical magnetite nanoparticles. The obtained experiences for achievement high specific heat power will enable the application magnetic nanoparticles at cancer treatment in biomedicine. We aim to investigate the shielding (absorption and reflection) effects of transformer oil based magnetic fluid. Besides the unique cooling and isolating properties, these magnetic fluids can be reliable shielding medium in electromagnetic devices as well. The research on radiation stability of MFs will address electromagnetic fields and another type radiation.
Duration: 1.1.2016 - 31.12.2019

Complementary study of superconductivity of selected materials
Komplementárne štúdium supravodivosti vybraných materiálov
Program: VEGA
Project leader: RNDr. Kačmarčík Jozef PhD
Annotation:Since the discovery of the two-gap superconductivity in MgB2 almost 15 years ago, a continuous search for other examples of this special feature is maintained. Another interesting issue of these days in condensed matter physics is investigation of materials with competing orders, where for example superconductivity coexists or compete with magnetic ordering or charge density waves. Within the project we will focus on study of several representatives of these groups – we will confirm or disconfirm presence of two energy gaps in LaRu4As12 and Bi2Pd, we will explore competing orders in CuxTiSe2 and CeCoIn5 and we will address spatially constrained superconductivity in granular doped diamond. Clarification of their superconducting mechanism could shed some light on other superconducting materials. We will also work on development of new experimental methods – implementation of a resistive calorimeter and mastering and further enhancement of local magnetometry using Scanning Hall-probe microscope.
Duration: 1.1.2016 - 31.12.2019

Magnetization and relaxation processes in magnetic particles and composites.
Magnetizačné a relaxačné procesy v magnetických časticiach a kompozitoch.
Program: VEGA
Project leader: RNDr. Kováč Jozef CSc.
Annotation:The project is oriented on experimental investigation of the structure and magnetic properties of magnetic particles with the size of several nanometers to several hundred micrometers. The particles (with amorphous, nanocrystalline, or polycrystalline structure) are based on ferromagnetic metals and alloys, and are covered with an inorganic or organic layer, and after technological treatments become precursors for the preparation of composites. The research is focused on investigation the magnetization and relaxation processes in ferromagnetic particles under different physical conditions as ferromagnetic phase content, temperature, amplitude and frequency of the magnetic field. Expected results will help to expand the application potential of this class of advanced materials for a variety of medical and technological applications.
Duration: 1.1.2016 - 31.12.2019

Magnetoelectric and magnetocaloric effect in exactly solvable lattice-statistical models
Magnetoelektrický a magnetokalorický jav v exaktne riešiteľných mriežkovo-štatistických modeloch
Program: VEGA
Project leader: RNDr. Čenčariková Hana PhD
Annotation:Magnetoelectric and magnetocaloric effects will be examined in detail with the help of exactly solvable lattice-statistical models including Ising spin systems, Ising-Heisenberg spin systems and coupled spin-electron systems, which consist of localized Ising spins and delocalized electrons. The primary goal of the project is to explore an influence of external electric field on basic magnetic properties and an influence of external magnetic field on basic thermodynamic properties of the studied lattice-statistical models. A response of magnetic system on a change of external electric and magnetic fields will be investigated mainly in a vicinity of phase transitions (including quantum ones), where particularly interesting behaviour can be expected. The rigorous theoretical results will contribute to a deeper understanding of both studied cooperative phenomena, what enables to propose a subsequent optimalization of technologically important properties of multifunctional materials and magnetic refrigerants.
Duration: 1.1.2016 - 31.12.2019

SUPRABULK - Bulk Superconductors
Masívne supravodiče
Program: APVV
Project leader: Ing. Diko Pavel DrSc.
Annotation:The project is focussed on the microstructural design of bulk superconductors. Bulk superconductors with selected substitutions will be prepared by already mastered TSMG process as well as by progressive infiltration technology and thermal treatments for redistribution or clustering of substitution will be applied. Secondary particles will be refined by additions of cerium compounds instead of commonly used platinum addition. The influence of preparation parameters and the type of cerium compound will be studied. The microscopic and macroscopic superconducting properties, structure and microstructure will be analysed. The comprehensive model of the microstructure nature of superconduting properies of these materials will be developed.
Duration: 1.10.2013 - 30.9.2017

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Matud Mihalik
Program: VEGA
Project leader: RNDr. Mihálik Matúš PhD.
Duration: 1.1.2016 - 31.12.2019

Mechanical properties and stability of amorphous alloys and nanosized systems
Mechanické vlastnosti a stabilita amorfných zliatin a nanorozmerných sústav
Program: VEGA
Project leader: RNDr. Csach Kornel CSc.
Annotation:The project is focused to solving some problems of plastic deformation and the processes of structural relaxation in amorphous metallic alloys . Analogies and differences in failure micromechanisms of strong defective structure characterized as amorphous, nanocrystalline or strong degenerated crystalline solid solution (in the case of highentropic alloys).
Duration: 1.1.2014 - 31.12.2017

MVISION - Nanoparticles in anisotropic systems
Nanočastice v anizotrópnych systémoch
Program: APVV
Project leader: Doc. RNDr. Kopčanský Peter CSc.
Annotation:The proposal is devoted to study complex anisotropic systems based on thermotropic as well as lyotropic (biological) liquid crystals. Liquid crystals represents the uniq state of matter, which is liquid but posses the anisotropic properties. The structuralization phenomena in such systems play key role in fundamental as well as in applied research. The main aim is to s influence the sensitivity of these anisotropic systems to external magnetic field, what will be done by adding suitable magnetic nanoparticles and open the way for their applications in magneto-optical devices.
Duration: 1.7.2016 - 30.6.2020

CRSPSW - Low energy cosmic rays, suprathermal particles and space weather
Nízkoenergetické kozmické žiarenie, supratermálne častice a kozmické počasie
Program: APVV
Project leader: Prof. Ing. Kudela Karel DrSc.
Duration: 1.7.2016 - 27.12.2017

MICROMANIP - Image analysis of microscopic particles in the automation of optical manipulation techniques applicable in mikro/nanorobotics.
Obrazová analýza mikroskopických častíc pri automatizácii optických manipulačných techník aplikovateľných v mikro/nanorobotike.
Program: APVV
Project leader: Doc. Ing. Tomori Zoltán CSc.
Annotation:Mikromanipulation based on the laser optical traps represents a progressive method of basic research in the physical, chemical and biomedical sciences. An analogy between the optical manipulation and the robotics evokes exploitation of the artificial intelligence algorithms (computer vision, machine learning, planning of trajectories, etc.). According to some authors, the use of these methods in combination with physical models has led to the significant increase of the effectiveness compared to the classic optimization (up to 1000 times in SVM classifier trained in advance using the Lorenz-Mie scattering light model). The aim of the project is to use a similar philosophy for the experimental tasks solved in our laboratory - cells sorting and fusing, their physical properties measurement and etc. Using the apparatus for 2-photon polymerization we plan to manufacture microrobotic instruments controlled by the optical tweezers traps, e.g. a mikrorobotic arm (gripper). As continuity with our previous project, we would improve the interactive control of optical tweezers via NUI interface (using the position of the fingers and gaze, voice, gestures). This interface should be functional not only locally, but also remotely over a network connection.
Duration: 1.7.2016 - 31.12.2019

Functional and Structural Insights into the Phospholipid-Protein Interaction during Oxidative Stress
Oxidačný stres a fosfolipidovo-proteínové interakcie: funkčné a štrukturálne dôsledky
Program: VEGA
Project leader: MUDr. Musatov Andrey DrSc.
Annotation:Mitochondria play a critical role in cells metabolism and mitochondrial dysfunction has long been implicated in age-related neurodegenerative diseases. One currently accepted theory is that damage to mitochondria, the main source of reactive oxygen species (ROS), initiates these diseases. In fact, when ROS levels overpower the cell’s defenses (oxidative stress), proteins, nucleic acids and/or lipids are irreversibly damaged. Particularly important is that oxidative stress disrupts or modifies the protein-lipid interactions what is one of the essential features of normal cell operation. Such disruptions could be a decisive factor leading to ROS-induced diseases. To test this hypothesis and clearly elucidate the links between mitochondrial oxidative stress and cells dysfunction we propose to investigate both, (i) the role of phospholipid modification in ROS-induced damage to mitochondrial electron transport Complex IV, and (ii) the role of phospholipids and oxidatively modified phospholipids in amyloidogenesis.
Duration: 1.1.2017 - 31.12.2020

PSI - Superconductor - insulator transition
Prechod supravodič - izolant
Program: APVV
Project leader: Mgr. Szabó Pavol CSc.
Annotation:The project aims at understanding the problem of how superconductor transforms to insulator at increased disorder. The questions of what is the force driving the superconducting transition temperature to lower values in ultrathin superconducting films and what is the mechanism of the quantum phase transition between superconducting and insulating states will be addressed experimentally as well as theoretically. The superconducting films of various content with thicknesses down to few atomic layers as well as the nanostructures and resonators on their basis will be prepared. Transport, microwave and optical properties of these objects will be investigated. By means of the subkelvin scanning tunnelling microscope the spectral maps of the quasiparticle density of states at ultralow temperatures and in high magnetic fields will be measured. We will explore possibilities to prepare sensitive photon detectors and amplifiers based on ultrathin disordered superconducting films for the spectroscopy in physics, chemistry and biology. Dynamics of the surface states in another macroscopic quantum object, the superfluid 3He which is the topological insulator at ultra low temperatures, will be investigated experimentally as well as theoretically. The objective is to elucidate the dynamics of surface bound excitations in superfluid 3He by means of mechanical resonators and resolve if the excitations can be identified with the long searched Majorana fermions. By experiment the recent question if samarium hexaboride is a topological insulator will be addressed.
Duration: 1.7.2015 - 30.6.2019

RGBD_Algorithms - Natural User Interface based on RGB-D Image Processing Algorithms and their Application in Biomedicine
Prirodzené užívateľské rozhranie na báze algoritmov spracovania RGB-D obrazu s využitím v biomedicíne
Program: VEGA
Project leader: Doc. Ing. Tomori Zoltán CSc.
Annotation:New types of 3D sensors are designed to capture the human body or its parts. Their output is usually RGB color image, depth map, as well as 3D coordinates representing the position of the hands, fingers, and the gaze direction. One of the objectives of the project is to improve the manipulation with microscopic particles by using optical tweezers so that the position of the laser traps are controlled by the position of the fingers acquired by the Leap Motion sensor. The second goal is to exploit 3D sensors to support the rehabilitation training in both the clinic environment and at home (telerehabilitation). Contactless system will warn the patient for deviations from the rehabilitation protocol, the output of the program is an evaluation score proposed in close cooperation of programmers with physiotherapists. In doing so, they used the principles of machine learning, computer games, data transmission over the network classifiers and the other techniques in the field of computer vision and graphics.
Duration: 1.1.2016 - 31.12.2018

Rapidly quenched amorphous and Heusler alloys with unique properties. Production and characterization.
Rýchlochladené amorfné a Heuslerove zilatiny s význačnými vlastnosťami. Príprava a charakterizácia.
Program: VEGA
Project leader: RNDr. Kováč Jozef CSc.
Annotation:The project is focused on research and development of new amorphous and Heusler alloys in the shape of ribbons and mainly microwires produced by rapid quenching method, which are characterized by unique properties ideal for technical applications. Mainly, we will deal with Fe-based microwires with magnetic bistability that is sensitive to magnetic field, temperature and mechanical stress. On the other hand, Heusler ribbons and microwires will be studied that are characterized by high spin polarization, magnetocaloric effect and shape memory effect. Small dimensions of these materials together with easy production of large amount of alloy allow their application in construction of miniaturized sensors and actuators.
Duration: 1.1.2016 - 31.12.2018

Rapidly quenched soft and hard magnetic composites for energy and sensor applications.
Rýchlochladené magneticky mäkké a magneticky tvrdé kompozitné materiály pre aplikácie v energetike a senzorike.
Program: VEGA
Project leader: RNDr. Škorvánek Ivan CSc.
Duration: 1.1.2016 - 31.12.2018

Satellite detectors for space physics research
Satelitné detektory pre kozmofyzikálny výskum
Program: VEGA
Project leader: Ing. Baláž Ján PhD.
Annotation: The proposed project aims to support currently running space projects at various phases, covering needs for electronic components, external mechanical Works on 5-axis centres, travel expenses dedicated to working meetings, tests, calibrations, launch campaigns. Current activities: - development of energetic particle spectrometer DOK-M for mission RESONANCE - development of energetic particle spectrometer ASPECT-L for mission LUNA-GLOB - development of UV photometer AMON for Slovak satellite skCUBE - participation on development of energetic neutral atom imager NAIS for Chinese MIT mission - participation on development of energetic particle suite PEP for mission ESA JUICE
Duration: 1.1.2016 - 31.12.2018

Supramolecular complexes of biomacromolecules
Supramolekulárne komplexy biomakromolekúl
Program: VEGA
Project leader: RNDr. Valušová Eva PhD.
Annotation:Cells have numerous examples of nonmembrane-bound compartments containing many biomacromolecules. However, their physicochemical properties play an important role in a number of biological processes, but their complex biochemistry still remain poorly understood. These granules exhibit liquid-like behavior. Two or more biomacromolecules that interact with each other form liquid droplets in which their concentration is higher than in the surrounding aqueous medium. Furthermore, high concentrations of solutes, ions and also some low - molecular weight molecules contribute to mesoscale organization in certain biological systems. The project is devoted to address processes allowing preparing and characterization physicochemical properties of supramolecular complex models of nonmembrane-bound compartments and will also concentrate on mechanisms that occur during these processes.
Duration: 1.1.2016 - 31.12.2019

Superfluid helium-3 as topological insulator
Supratekuté hélium-3 ako topologický izolátor
Program: VEGA
Project leader: RNDr. Skyba Peter DrSc.
Duration: 1.1.2015 - 31.12.2017

SUMAC - Superconducting and magnetocaloric ceramics
Supravodivá a magnetokalorická keramika
Program: VEGA
Project leader: Ing. Diko Pavel DrSc.
Annotation:Research under the project will be focused mainly on understanding the complex phenomena associated with the crystallization of REBCO bolk singlecrystalline superconductors and the development of new efficient processes for their preparation. Part of the capacity will be devoted to research bulk superconductors based on superconducting pnictides and to search for new superconducting materials suitable for making bulk superconductors. Research of magnetocaloric ceramics based on perovskite manganites with a structure similar to REBCO superconductor, will focus on the preparation of new composite materials with a wide magnetic phase transitions suitable for practical applications. The project will be designed in cooperation with foreign universities and research centers: SIT Tokyo; Cambridge University; CRISTMAS Caen; JTU Shanghai; CNRS Grenoble; KAERI South Korea.
Project web page:WWW.saske.sk
Duration: 1.1.2016 - 31.12.2018

Magnetic properties of selected 3d metal-oxides based multiferroics
Štúdium magnetických vlastností vybraných multiferoických materiálov na báze oxidov 3d kovov
Program: VEGA
Project leader: RNDr. Zentková Mária CSc.
Duration: 1.1.2016 - 31.12.2018

Study of the intrinsically disordered protein stability and aggregation
Štúdium stability a agregácie natívne rozbalených proteínov
Program: VEGA
Project leader: RNDr. Fedunová Diana PhD.
Annotation:Intrinsically disordered proteins (IDPs) – proteins without ordered stable structure at physiological conditions – are of great interest especially due to their connections to neurodegenerative diseases. Alzheimer’s disease is characterized by deposits of amyloid plaques or neurofibrillary tangles, formed by fibrous assemblies of the A-beta or tau proteins. The growing evidences indicate that oligomers are more toxic species than fibrils. Proposed projects is oriented on study of the effect of external conditions (pH, T, ionic strength, hydrophobicity) and various compounds (denaturants, osmolytes and polyanions) on conformation of tau and A-beta proteins and kinetics of their oligomerization. Another goal is to define how properties of oligomers affect the kinetics of ibrillization and morphology of obtained amyloid fibrils.
Duration: 1.1.2014 - 31.12.2017

Study of superconducting nanostructures and nanolayers
Štúdium supravodivých nanoštruktúr a nanovrstiev
Program: VEGA
Project leader: Prof. RNDr. Samuely Peter DrSc.
Duration: 1.1.2015 - 31.12.2018

NANOSIMKA - Effects of nanoencapsulated simvastatin on cardiovascular system in experimental metabolic syndrome
Účinok nanoenkapsulovaného simvastatínu na kardiovaskulárny systém pri experimentálnom metabolickom syndróme
Program: APVV
Project leader: Ing. Závišová Vlasta PhD.
Annotation:High level of cholesterol in the blood increases the risk of heart and vascular diseases. Simvastatin reduces cholesterol production in the liver thus reduces the blood cholesterol level. Long-term use of statins has been associated with the occurrence of side effects, which in addition increase with increasing their dose. In particular, the statin side effect include mainly inhibition of the endogenous synthesis of CoQ10 - basic cofactor for ATP synthesis and paradoxically activation of PCSK9 - an important enzyme for the synthesis of LDLcholesterol. The project aims to increase the bioavailability of simvastatin in the liver, thus reducing the daily dose and consequently to prevent the reduction of CoQ10 levels as well as to block the activation of PCSK9. In order to achieve this this aim, nano-encapsulated simvastatin together with nano-encapsulated CoQ10 or PCSK9 inhibitor, or in the polymer with antioxidant properties will be prepared, tested and applied. This ensures the targeted transport of simvastatin to the liver simultaneously with CoQ10, or inhibitor of PCSK9, or simultaneous increase in antioxidant capacity. In the case of successful results the proposed project may uncover new possibility of using nanocarriers for the treatment of metabolic and cardiovascular diseases.
Duration: 1.7.2015 - 30.6.2019

The role of surface states in samarium hexaboride and other valence-fluctuating systems exhibiting metal-insulator transition
Úloha povrchových stavov v hexaboride samária a iných zmiešanovalenčných systémoch vykazujúcich prechod kov-izolátor
Program: VEGA
Project leader: RNDr. Baťková Marianna PhD.
Annotation:Samarium hexaboride (SmB6) represents an important model system exhibiting metal-insulator transition. A mysterious property of this valence fluctuating semiconductor is that at lowest temperatures it does not reveal divergency of electrical resistivity, but behaves as a metal. SmB6 is nowadays intensively studied also as a possible topological insulator, while metallic topologically protected surface is considered to be a reason of absence of insulating ground state. However, the latest results provide evidence about trivial surface states in SmB6. The project aims to evaluate the role of surface states in electrical conduction of SmB6 by investigating SmB6 thin films, to evaluate relevance of the scenario of topological insulator and other alternative approaches to explain electrical conductivity in SmB6, thus to contribute to understanding the nature of electronic transport in SmB6 and similar systems.
Duration: 1.1.2017 - 31.12.2020

Variability of cosmic ray flux measured on Earth's surface
Variabilita kozmického žiarenia meraného na zemskom povrchu
Program: VEGA
Project leader: Prof. Ing. Kudela Karel DrSc.
Duration: 1.1.2016 - 31.12.2017

Properties of nuclear matter created in interactions with nuclear targets at high energies
Vlastnosti jadrovej matérie vytvorenej v interakciách s jadrovými terčíkmi pri vysokých energiách
Program: VEGA
Project leader: RNDr. Nemčík Ján CSc.
Annotation:The main goal of the present project is theoretical study of nuclear effects, manifestations and properties of nuclear matter created in various reactions on nuclear targets at high energies corresponding mainly to experiments at Relativistic Heavy Ion Collider (RHIC) a Large Hadron Collider (LHC).
Duration: 1.1.2014 - 31.12.2017

Effect of extreme environment (magnetic field, pressure, temperature) on the anomalous behavior of the ground state and phase transitions in strongly correlated materials.
Vplyv extrémnych podmienok (magnetické pole, tlak, teplota) na neobvyklé chovanie základného stavu a fázové prechody v korelovaných látkach
Program: VEGA
Project leader: RNDr. Mihálik Matúš PhD.
Annotation:Nowadays, the trend in research of rare-earth intermetallic compounds is the shift of the interest towards the physical phenomena like Kondo behavior, non-Fermi liquid behavior, or quantum critical point. It has turned out that these exotic types of behavior can be observed in Ce, Yb, or U-based compounds. During the project we will prepare and characterize polycrystals and single crystals from Ce – Ni – Ge; Ce – Co – Ge, U - Ni – Ge and U – Co – Ge ternary systems. The main objective of our project is search for quantum criticality in these antiferromagnetic and ferromagnetic systems and generating quantum fluctuations by suitable chemical doping (Co-Ni substitution; or Ge-Si substitution), high pressure and magnetic field. The additional objective is seeking for the novel materials targeted U-based ternary intermetallic compounds.
Duration: 1.1.2016 - 31.12.2018

Influence of extreme conditions on strongly correlated electron systems
Vplyv extrémnych podmienok na silne korelované elektrónové systémy.
Program: VEGA
Project leader: RNDr. Gabáni Slavomír PhD.
Annotation:Strong correlations between free (conduction) and bound (localized) electrons in a condensed matter can be change or modified by extreme conditions (very low temperatures, high pressures and magnetic fields), what often leads to the creation of new/exotic states/effects in these materials. In this proposal, we will experimentally study the newest open problems in strongly correlated electron systems (SCES), as surface conductivity in topological Kondo insulators, dynamics of frustrated antiferromagnets, Kondo vs. spin-polaron model in spin glasses, superconductivity under pressure. All this will be a very time-consuming research on new-produced samples.
Duration: 1.7.2016 - 31.12.2019

Development of new procedures for the reconstruction and analysis of the data from the proton-proton collisions at the LHC
Vývoj nových postupov pre rekonštrukciu a analýzu dát z protón-protónových zrážok na urýchľovači LHC
Program: VEGA
Project leader: RNDr. Kladiva Eduard CSc.
Annotation:Theoretical as well as methodological contribution to studies of proton interactions at LHC accelerator, which was just upgraded to a new, so far the highest energy of proton-proton collisions, is proposed in this project. The project goal is to contribute to the improvements of existing reconstruction and analysis procedures, as well as to bring up new aspects from theoretical and methodological points of view. The main contribution to methodology will be the improvement of the hadronic calibration of the ATLAS calorimeter. Contribution to the accuracy improvement of b-jet charge calibration is also foreseen. We assume three main contributions to the analysis, namely improvements of the top-quark charge measurement, searches for Higgs boson and searches for Standard Model (SM) extensions, as well as to obtain improved data to study Bose-Einstein correlations between the pions produced in proton collisions.
Duration: 1.1.2016 - 31.12.2019

Projects total: 48