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Institute: Institute of Animal Physiology

Bioactive substances, their impact and utilization for animals health
Bioaktívne substancie, ich význam a využitie pre zdravie zvierat
Program: VEGA
Project leader: MVDr. Lauková Andrea CSc.
Annotation:Occurrence of the species Enterococcus hirae (in the framework of phylum Firmicutes) will be screened in animals population with the aim to check positive properties (production of bacteriocin-hiracin) but also properties with negative impact (virulence factors) as well as another properties (biofilm formation) regarding to the comparative studies following the basic research because this species isolated from animals sources have been not detaily studied up to now. Possibilities to use bioactivity of selected strain, effect of hiracin produced by that strain to balance health condition in husbandry will be tested following beneficial results (e.g. phagocytic activity stimulation) after bacteriocins applications achieved in our previous projects. Also inhibitory spectrum of bacteriocin (previously characterized at our laboratory) will be checked against Enterococcus hirae strain with virulence factors genes and bacteriocin application form too.Selected strain will be deponed to the culture collection.
Duration: 1.1.2017 - 31.12.2020

Small mammals as a potential source of zoonotic bacteria and resistance to antibiotics
Drobné cicavce ako potenciálny zdroj zoonotických bakterií a rezistencie na antibiotiká
Program: SRDA
Project leader: Prof., MVDr. Kmeť Vladimír DrSc.
Annotation:This project aim to yield fundamentally new and to significantly broaden current knowledge on the components of natural foci with a focus emerging diseases in conditions of global changes.
Duration: 1.7.2015 - 30.6.2019

Firmicutes, their properties and utilisation for animal health
Firmicutes, ich vlastnosti a využitie pre zdravie zvierat
Program: VEGA
Project leader: MVDr. Strompfová Viola PhD.
Annotation:The complex communities of microorganisms that colonise the gastrointestinal tract of animals and humans play important role in health ensurance because it exists association between composition and diversity changes in the intestinal microbiota and several diseases. Although one of predominant bacteria in healthy digestive tract of microbiota is phylum Firmicutes, its importance and possible beneficial effect in companion and sporting animals is only at the beginning of research. Therefore, the aim of submitted project is to achieve knowledge on species occurence and in vitro properties (metabolic and probiotic) of selected representatives of phylum Firmicutes isolated from horses and dogs. Selected strains will be tested in model in vivo experiments whereby microbiological, haematological, biochemical and immunological parameters will be detected. The results could spread till now limited knowledge on abundance and characteristics of Firmicutes in mentioned animals and bring new insights for their use.
Duration: 1.1.2016 - 31.12.2019

Komplexný pohľad na vplyv prídavných látok na organizmus zvierat
Program: VEGA
Project leader: Prof. MVDr. Faix Štefan DrSc.
Duration: 1.1.2017 - 31.12.2020

Digestive modulation by phytogenic and mineral feed additives in farm animals
Modulácia tráviacich procesov u hospodárskych zvierat naturálnymi a minerálnymi aditívami
Program: VEGA
Project leader: MVDr. Grešáková Ľubomíra PhD.
Annotation:Proposed project is focused on the effect of phytogenic extracts (tannins, saponins, essential oils, polyphenols) and mineral-organic complexes on the metabolism and their mutual interaction in gastrointestinal tract of farm animals. Due to the prohibition to use of antibiotics and other chemicals in the EU countries, the supplementation of feedstuffs by phytogenic substances and organic mineral additives is desirable. It seems that use these feed additives as potential natural alternatives can lead to the higher animal productivity and simultaneously minimize the environmental pollution. We will investigate the influence of plant extracts on the gastrointestinal metabolism focused on the methanogenesis reduction and the improvement of microbial fermentation. The impact of Zn and Mn feed supplementation from their new organic sources on their absorption and deposition in animal tissues as well as the antioxidant status of livestock will also be investigated.
Duration: 1.1.2017 - 31.12.2020

Molecular analysis of microbial biofilm in animal. 
Molekulárna analýza mikrobiálneho biofilmu u zvierat.   
Program: VEGA
Project leader: RNDr. Bujňáková Dobroslava PhD
Annotation:The basic objective of the project is obtaining a new knowledge about biofilm formation in relationship to virulence factors and phenotypic antibiotic resistance on model species of animal bacteria: Enterobacteriaceae (Klebsiella, Escherichia), Staphylococcus sp. and non-fermenting Gram-negative rods (Pseudomonas sp.). Molecular-biological analysis will be oriented to the 16S rRNA detection of the species composition of animal intestinal bacterial biofilm and for detection of genes encoding uptake of trivalent iron (siderophores) from the host proteins as an essential factor of host-microbial interactions. The effect of plant secondary metabolites and bacterial surfactants to biofilm formation and virulence factors expression will be also monitored. The reached results will be useful in applied research for the development of innovative anti-bacterial and anti-biofilm strategies, in veterinary and food diagnostic laboratories and also in student education.
Duration: 1.1.2018 - 31.12.2020

Molecular mechanisms of preimplantation embryo adaptation
Molekulárne mechanizmy adaptácie preimplantačného embrya
Program: VEGA
Project leader: Prof. MVDr. Koppel Juraj DrSc.
Annotation:The proposed project studies early embryo development in relation to maternal status, and is focused especially on the maternal stress. Two aspects of maternal stress influences will be solved concurrently within the project. Firstly, physiological effects of maternal stress acting during the preimplantation developmental period will be studied. The influence of maternal stress, with respect to maternal metabolic status, on the preimplantation embryo quality will be analyzed. Long-term effects of maternal stress acting in the preimplantation period will be studied as well. Secondly, molecular mechanisms by which stress mediators act in cells of preimplantation embryos will be studied. In vitro experiments will be focused on studies of the signaling pathways activated by stress mediators at DNA damage.
Duration: 1.1.2015 - 31.12.2018

Impact of selected xenobiotics on honeybee (Apis mellifera)
Negatívny vplyv vybraných xenobiotík na larválne štádium včely medonosnej (Apis mellifera)
Program: VEGA
Project leader: Doc. RNDr. Javorský Peter DrSc.
Annotation:Substantial percentage of world food production depends on pollinating service of honeybees which depends directly on their health status. There is an increased concern on bee health in the world, because of their irreparable place in ecosystem and industry. There is a tendency of decreased numbers of bee colony in the world, which is said due to pollution. Main aim of this project is implementation of in vitro methodology of testing of xenobiotics (pesticides and drugs) on larval stage of honeybee (Apis mellifera) in accordance with valid OECD method Nr. 237 in Slovakia.
Duration: 1.1.2016 - 31.12.2018

Progresive methods for elimination of development and sprad of bacterial resistance against relevant antibiotics
Progresívne metódy zabraňujúce vzniku a šíreniu rezistencie baktérií voči klinicky relevantným anibiotikám
Program: SRDA
Project leader: Doc. RNDr. Javorský Peter DrSc.
Annotation:Antibiotic resistance currently represents so serious problem in human and veterinary clinical practice that has become a priority of many important international and world organizations such as FAO, WHO, EFSA, etc. Dissemination and incidence of antibiotic and antibiotic resistant strains in the environment greatly contributes to increased globalization of this problem. Nowadays bacterial resistance associated with a consequent reduction in efficiency and an arsenal of usable antibiotics is not only problem of hospitals. As pointed out by many studies,resistant microorganisms can be found increasingly in wastewater, agriculture, food, as well as in humans or animals. The project therefore aims on analysis of antibiotic resistant bacteria prevalence in selected environments closely related to human activities. Project is targeted also on study of the genetic material related to antibiotic resistance in these environments, as well as on processes supporting an increase in antibiotic resistance. Following the fact that wastewater from hospitals and the community represents a significant reservoir of antibiotic resistant bacteria and resistance genes, the project will focus mainly on the development and monitoring the effectiveness of innovative degradation processes (Fenton reaction, boron-doped diamond electrodes Ferrates) targeted on the elimination of bacteria and genes in the wastewater.
Duration: 1.7.2017 - 30.6.2020

Anthelmintic resistance of parasites – challenges, perspectives and solutions
Rezistencia parazitov na antihelmintiká-výzvy, perspektívy a riešenia
Program: SRDA
Project leader: MVDr. Váradyová Zora PhD
Annotation:The project addresses significant issues, resistance to anthelmintics in parasitic nematodes of small ruminants. In the project we want to map out the shortcomings of currently available in vitro methods for identifying resistance using molecular methods. In addition, we examine in vitro and in vivo efficacy of selected mixtures of plants in experimentally infected sheep. With respect to increasing interest in the therapeutic use of natural products, it is very important systematic evaluation of the botanical resources on pasture in relation to the purported de-worming properties of those plants that are endemic and thrive in this region. Therefore, one of the objectives of this project would be to use plant mixtures supplemented with selected plants against parasites into the feed ration of experimentally infected sheep. Use of plants with anthelmintic effect in the form of supplemented mixtures to the feed ration is one of the options of control the nematode infections in breeding of small ruminants.
Duration: 1.7.2015 - 28.6.2019

Xenobiotics and preimplantation embryo development
Xenobiotiká a vývin preimplantačného embrya
Program: SRDA
Project leader: Prof. MVDr. Koppel Juraj DrSc.
Annotation:The proposed project investigates the effects of selected xenobiotics on early embryo development. The project will be focused on two groups of substances with oral poisoning potential for farm and domestic animals or human: insecticides and food additives. Their impact on early female reproductive capacity will be assessed in two laboratory animal models: mouse and rabbit. The project will study the influence of maternal intoxication on the fertilization, developmental capacity of oocyte and preimplantation embryo and embryo implantation. Beside standard toxicological approach, the study will revalue obtained results in the context of maternal environment (i.e. in the context of actual physiological and metabolic status). Furthermore, in substances with proved detrimental effect, molecular mechanisms of their action will be evaluated.
Duration: 1.7.2015 - 30.6.2019

The total number of projects: 11