The list of national projects SAS

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Institute: Institute of Experimental Physics

Amyloid aggregation of proteins in hybrid interfaces
Amyloidná agregácia proteínov na hybridných povrchoch
Program: Inter-academic agreement
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:The aim of the project is a study of the mechanism of aggregation of the different amyloid proteins induced by interaction with various surfaces. The main focus will be concern on the characterization of protein aggregation induced by protein interaction with solid interfaces with various geometrical as well as the chemical properties of the surfaces. We will investigate the role of the surface forces and dimensionality of nanoparticles as agents that accelerate or prevent amyloid fibrillization of proteins. Moreover, effect of the interface polarity, substrate roughness or geometrical constraints will be examined. We will compare the morphological properties of amyloid aggregates formed in solution and at solid interface.
Duration: 11.1.2016 - 31.12.2017

ALICE experiment at the CERN LHC: The study of strongly interacting matter under extreme conditions
Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach
Program: CERN
Project leader: RNDr. Králik Ivan CSc.
Annotation:The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties.
Duration: 1.1.2016 - 31.12.2020

ATLAS experiment on LHC in CERN: deep-inelastic events and new physics at TeV energies
Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách
Program: CERN
Project leader: Doc. RNDr. Bruncko Dušan CSc.
Duration: 1.1.2016 - 31.12.2020

JEM-EUSO, Extreme Universe Space Observatory Onboard Japan Experiment Module
JEM-EUSO, Kozmické Observatórium Extrémneho Vesmíru na palube Japonského Experimentálneho Modulu
Program: Multilateral - other
Project leader: RNDr. Bobík Pavol PhD
Annotation:Research of extreme energy cosmic rays with use of observations of secondary responses in the atmosphere of Earth from the International space station
Duration: 1.1.2010 - 31.12.2017

Magnetic properties of tetraborides
Magnetické vlastnosti tetraboridov
Program: Bilateral - other
Project leader: Doc. RNDr. Flachbart Karol DrSc.
Duration: 0.0.0000 - 31.12.2017

Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy
Multifunkcionalizované nanočastice pre magnetickú hypertermiu a nepriamu radiačnú
Program: COST
Project leader: Doc. RNDr. Kopčanský Peter CSc.
Annotation:The Action aims to bring together and to organise the research outcomes from the different participating network members in a practical way to provide clinicians with the necessary input to trial a novel anti-cancer treatment combining magnetic hyperthermia and radiotherapy, also identifying future research objectives upon appraisal of the obtained results. Feedback between the different working groups here is essential, and is expected that the lifetime of this Action proposal will eventually result in a compendium of best practices for magnetic hyperthermia.RADIOMAG will generate new and strengthen the existing synergies between technical advances (thermal imaging / MH), new treatment concepts (combined targeting radiosensitisation and magnetic thermotherapy) and biocompatible coating in order to achieve a breakthrough in the clinical application of magnetic hyperthermia. Due to the complexity of this aim, synergies can only be achieved on a longer time frame, by means of workshops, STSMs, joint publications, common Horizon 2020 research proposals and exchange with other COST Actions (e.g. TD1004, TD1205).
Duration: 13.11.2014 - 12.11.2018

Non-globular proteins - from sequence to structure, function and application in molecular physiopathology
Neglobulárne proteíny - od sekvencie ku štruktúre, funkcii a aplikácii v molekulárnej fyziopatológii
Program: COST
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Non-globular proteins (NGPs) encompass different molecular phenomena that defy the traditional sequence-structure-function paradigm. NGPs include intrinsically disordered regions, tandem repeats, aggregating domains, low-complexity sequences and transmembrane domains. Although growing evidence suggests that NGPs are central to many human diseases, functional annotation is very limited. It was recently estimated that close to 40 of all residues in the human proteome lack functional annotation and many of these are NGPs. While a better understanding of NGPs is crucial to fully comprehend human molecular physiopathology, progress has been hampered so far by the lack of a systematic approach to their study.This Action Proposal aims to create a pan-European scientific network of groups that work on NGPs to strengthen, focus and coordinate research in this field. It proposes to develop a novel classification of NGPs by consensus among interested experts that will be showcased on a newly developed web site, along with meetings, training schools and scientific missions on NGP-related topics.
Duration: 27.7.2015 - 25.3.2019

Overcoming Barriers to Nanofluids Market Uptake ( NANOUPTAKE)
Prekonanie bariiér pre komerčné využitie nanokvapalín (NANOUPTAKE)
Program: COST
Project leader: RNDr. Timko Milan CSc.
Annotation:Nanofluids are defined as fluids that contain nanometre-sized particles with enhanced heat transfer properties. Nanofluids improve the efficiency of heat exchange and thermal energy storage. In addition, nanofluids fall within one of the Key Enabling Technologies (KET) supported by the European Commission. Although some nanofluid commercial applications currently exist, most of the current nanofluids are at Technological Readiness Levels (TRL) 1 to 3. Most of the nanofluids research in COST countries has been conducted by Research, Development and Innovation (R+D+i) centres through national funding. Additional coordinated research and development efforts are required to develop nanofluids up to higher TRL levels and to overcome commercial application barriers. If these barriers are overcome, nanofluids will be an important player in the Value Added Materials (VAM) for the energy sector.The objective of the NANOUPTAKE COST Action is to create a Europe-wide network of leading R+D+i institutions, and of key industries, to develop and foster the use of nanofluids as advanced heat transfer/thermal storage materials to increase the efficiency of heat exchange and storage systems.
Duration: 19.4.2016 - 18.4.2020

Radiačné polia v blízkosti Zeme: možné súvislosti s kozmickým žiarením meraným na zemskom povrchu
Program: Inter-academic agreement
Project leader: Prof. Ing. Kudela Karel DrSc.
Duration: 1.1.2015 - 31.12.2017

Spectroscopic, transport and thermodynamic properties of strongly-correlated electronic systems with competing orders
Spektroskopické, transportné a termodynamické vlastnosti silno korelovaných elektrónových systémov s konkurenčnými parametrami usporiadania
Program: Inter-academic agreement
Project leader: RNDr. Vargaeštoková Zuzana PhD
Duration: 1.1.2015 - 31.12.2017

Study of the protein amyloid aggregation in vitro and in cerebrospinal fluid
Štúdium amyloidnej agregácie proteínov in vitro a v mozgomiešnom moku
Program: Inter-institute agreement
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Study of the amyloid aggregation of the protein in vitro and in the samples of the cerebrospinal fluid of the peoples with amyloid-related disease which obtain protein aggregation in vivo.Test of the assay for cerebrospinal fluid of the dementic and non-dementic peoples.
Duration: 13.7.2015 - 31.12.2020

Comprehensive studies of novel magnetic materials
Štúdium nových magnetických materiálov
Program: Inter-academic agreement
Project leader: RNDr. Zentková Mária CSc.
Duration: 1.1.2016 - 1.1.2018

Effect of small molecules and nanoparticles on amyloid aggregation of poly/peptides
Účinok malých molekúl a nanočastíc na amyloidnú agregáciu poly/peptidov
Program: Bilateral - other
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:This project is aimed at examining the self-assembly of proteins into amyloid aggregates, one of the hallmarks of AD and other amyloidosis. Accordingly, there is a considerable world-wide interest to identify molecular entities that can influence the amyloid aggregation in order to facilitate the drug development for amyloid diseases. The main goals of the project are to estimate the conditions required for promoting protein misfolding, to determine the cytotoxicity of amyloid aggregates, and to identify the compounds (e.g. small molecules and nanoparticles) that are able to inhibit protein aggregation using in vitro and in silico methods. The bilateral collaboration will allow to combine expertise and experience of both partners in the field of protein aggregation and acquire complex data with aid of complementary approaches, leading to a better understanding of amyloid aggregation mechanisms. The use of equipment provided by both institutions will offer a solid background for team members in order to publish their results at conferences and in journals. Moreover, this collaborative research partnership will present an excellent opportunity for both teams’ young members to learn new techniques in the well-equipped laboratories at NTU and SAS and work as an international scientific research group.
Duration: 11.1.2016 - 31.12.2018

The multitarget low molecular compounds from traditional Chinese herbs in treatment of Alzheimer´s disease
Využitie multitargetových nízkomolekulových látok z tradičných čínskych bylín pri liečbe Alzheimerovej choroby
Program: Bilateral - other
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Alzheimer's disease (AD) is a devastating neurodegenerative disorder of multifactorial nature characterized by neuroinflammation, decreasing the level of the neurotransmitter acetylcholine as well as formation of amyloid Abeta peptide plaques and neurofibrillary tangles containing abnormally posttranslationally modified tau protein. There is no effective treatment for AD so far and none of the clinically tested drugs have any feasibility to stop, substantially delay or reverse the progressive consequences of this disease. Accordingly, there is a considerable world-wide interest to facilitate the drug development for AD. Recently, the strategy of using the multi-targeted ligands seems to be the most attractive for developing effective therapy for Alzheimer´s disease due to ability of these compounds interacts with multiple targets responsible for the disease pathogenesis. The main goal of this project is to investigate multi-target responsibility of compounds including extracts from traditional Chinese herbs as potential therapeutic agents for AD. Using in vitro, in vivo and in silico methods we will study ability of these compounds to affect the neuroinflammation, to inhibit acetylcholinesterase activity, and amyloid aggregation of Abeta peptide. The bilateral collaboration will allow the both research groups to combine their expertise and experience in the field of pathology of Alzheimer´s disease. The complementary approach allows obtain more complex data leading to suggestion of possible alternatives of therapy against this devastating disease. Moreover, the project will also enable mutual utilization of equipment provided by both institutions. At the same time the young members of project's team will have the opportunity to learn new techniques in well-equipped laboratories at SAS and East China University of Science and Technology and also work in the international scientific team.
Duration: 1.1.2016 - 31.12.2017

The total number of projects: 14