The list of national projects SAS

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Institute: Institute of Parasitology

Dominant rodents in large towns and their potential risk as reservoirs of infectious agents
Dominantné hlodavce veľkých miest a ich potenciálne riziko ako rezervoárov infekčných agens
Program: Inter-academic agreement
Project leader: RNDr. Mošanský Ladislav PhD.
Duration: 1.1.2016 - 31.12.2017

European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells
Európska sieť pracovísk zaoberajúcich sa výskumom regulácie myeloidných buniek
Program: COST
Project leader: RNDr. Hrčková Gabriela DrSc.
Annotation:In cancer, infection and inflammation, the immune system’s function can be dysregulated, contributing to disease pathology. As part of this process, instead of fighting disease, immune cells may suppress beneficial immune responses and increase pathology. Despite their pathophysiological importance, the identity and biology of the so called myeloid regulatory cells (MRCs) is poorly understood. Depending on the MRC subtype and the respective disease, conflicting results have been published. This Action will form a network of researchers and clinicians which aims to establish a gold standard of common protocols and harmonizing guidelines for the analysis and clinical monitoring of MRCs. There is also a deficit in the translation of findings from animal models to humans, and Mye-EUNITER will build an analytical mouse-monkey-man correlation line. Standardized and validated tools for MRC analysis will aid the development of cellular biomarkers of disease and guide the design of novel therapies to manipulate the functions of MRCs.
Duration: 12.5.2015 - 26.11.2018

European Network for Foodborne Parasites (EURO-FBP)
Európska sieť pre potravinami prenášané parazity.
Program: COST
Project leader: MVDr. Dvorožňáková Emília PhD.
Annotation:The main objective of EURO-FBP is to decrease the impact on human health from foodborne parasites (FBP), through establishing a risk-based control programme for FBP containing robust and appropriate protective strategies. EURO-FBP will use an interdisciplinary, One Health perspective to assimilate information, coordinate research and harmonize diagnostics, surveillance, analytical methods, potential interventions and mapping of global trends regarding FBP. The Action will determine those FBP of greatest regional importance, pinpoint knowledge gaps, and focus resources strategically for control of FBP. FBP include protozoa, nematodes, cestodes and trematodes. Although a significant public health issue, FBP have been neglected compared with other foodborne pathogens such as viruses or bacteria. Furthermore, globalisation and changes in climate, agricultural practices, and human behaviour and lifestyles all contribute to emergence of FBP in new settings, with new hosts and transmission routes. Previously associated with specific regions, FBP are now spreading. FBP research is fragmented and groups often focus on a single genera or group of parasites. Hence COST is ideal for EURO-FBP, enabling collaboration among scientists that rarely interact. The agenda will focus on how to address FBP, optimising efforts and resources in order to control FBP in Europe - and globally.
Duration: 30.3.2015 - 29.3.2019

Immunological and molecular diagnostics of parasitic diseases of rodents living in different ecosystems of the national parks in Poland and Slovakia
Imunologická a molekulárna diagnostika pôvodcov parazitárnych chorôb hlodavcov žijúcich v rôznych ekosystémoch národných parkov Poľska a Slovenska
Program: Inter-academic agreement
Project leader: MVDr. Dvorožňáková Emília PhD.
Annotation:The main aim of the project is to study occurrence and prevalence of such important parasitic diseases as: echinococcosis (Echinococcus multilocularis, Echinococcus granulosus), trichinellosis, toxoplasmosis, neosporosis, babesiosis, anaplasmosis, borreliosis and ehrlichiosis in the Białowieża Primeval Forest (Poland) and the Tatra National Park (Slovakia) in the rodents’ hosts. Proven immunological and molecular methods can provide reliable results.
Duration: 1.1.2016 - 31.12.2018

Tick-borne diseases zoonotic foci in urban habitats of Poland and Slovakia
Kliešťami udržiavané ohniská ochorení zoonotického charakteru v mestách Poľska a Slovenska (2016 – 2018).
Program: Inter-academic agreement
Project leader: doc. RNDr. Stanko Michal DrSc.
Annotation:Ticks are worldwide haematophagous parasites on humans and domestic animals.T ick species found in towns in central Europe are Argas reflexus (Argasidae), Ixodes ricinus, I. hexagonus and Dermacentor reticulatus (Ixodidae). These ticks are vectors of human and animal zoonotic diseases, the most important are rickettsioses, Lyme-disease, HGE, babesiosis. The zoonotic foci of tick-borne diseaseas are situated mainly in natural environment, however, many infection cases are acquired in urban aglomeration. The goal of the project is the description of the zoonotic foci in big agglomerations in Poland and Slovakia, outlines the biology and the medical significance of tick species which colonize urban and suburban environments, their associations with small mammals, and describing the ecological circumstances of their occurrence. The second aim of this study is to estimate the risk of infection of mammals and hard ticks by the agents of tick-borne diseases (Lyme disease, anaplasmosis, babesiosis, rickettsioses) and risk of their transmission to human.
Duration: 1.1.2016 - 31.12.2018

Mechanisms of antiparasitic effects of silymarin flavonolignans on model larval cestode Mesocestoides vogae
Mechanizmy antiparazitického účinku silymarinových flavonolignanov na larvy modelovej pásomnice Mesocestoides vogae
Program: Inter-academic agreement
Project leader: RNDr. Hrčková Gabriela DrSc.
Annotation:As many as two billion individuals harbor helminth parasites, all of which often result in debilitating morbidity. The control of parasitic diseases is made with synthetic anthelmintics but appearance of resistance stimulated research of plant-based compounds. Helminth parasites have the complex life cycle, in which larval stages are responsible for the most severe pathology, including liver fibrosis. Flavonoid silymarin is a mixture of flavonolignans isolated from Silibum mariannun and it has proven antioxidant, hepatoprotective, immunomodulatory activities and can selectively kill cancer cells. The significantly increased efficacy of antihelmintic therapy was documented after silymarin co-administration on model larval flatworm (Cestoda) infection by Mesocestoides vogae in the liver and peritoneal cavity of mice, but mechanisms of its antiparasitic effect are unknown. Silymarin flavonolignans can regulate cell-signalling pathways and receptors in a different manner thus influencing its final activity. In present project the effects of isolated flavonolignans will be examined for the first time on this model parasite looking on key physiological, biochemical and molecular mechanisms.
Duration: 1.1.2016 - 31.12.2017

Molecular epidemiology of serious parasitoses of humans and animals (toxoplasmosis, neosporosis)
Molekulárna epidemiológia závažných parazitóz ľudí a zvierat (toxoplazmóza, neosporóza)
Program: Inter-academic agreement
Project leader: Ing. Reiterová Katarína DrSc.
Annotation:The project will build on previous research on toxoplasmosis and neosporosis and will be widened with epidemiological study of toxoplasmosis in humans.Toxoplasma gondii and Neospora caninum are widely distributed in domestic and wildlife circulations of different areas in Slovakia and Poland. The observation of the occurrence and expansion of both intracellular coccidia, causative agents of neosporosis and toxoplasmosis in farm and wildlife animals - possible definitive and intermediate hosts - will be monitored, with accent to obtain isolates of the parasites.
Duration: 1.1.2016 - 31.12.2018

Monitoring of the occurrence of zoonotic tick borne pathogens in urban areas of Central Europe under the impact of global climate changes
Monitoring výskytu zoonóznych druhov kliešťami prenášaných patogénov v mestských aglomeráciách Strednej Európy pod vplyvom globálnych klimatických zmien.
Program: Inter-academic agreement
Project leader: RNDr. Víchová Bronislava PhD.
Duration: 1.1.2015 - 31.12.2017

Emerging and Re-emerging Zoonotic Parasitosis Caused by Fish-Borne Parasites: Health Risks Associated with Consumption of Fish
Novo sa objavujúce rybami prenášané zoonózy: zdravotné riziká spojené s konzumáciou rýb
Program: Bilateral - other
Project leader: RNDr. Oros Mikuláš PhD.
Annotation:Consume raw and improperly cooked fishes may transmit fish-borne zoonotic diseases, which are currently (re-)emerging also due to population movement and climate changes. The aims of proposed collaborative project are focused on to the assessment of present occurrence, host associations, and current distribution and transmission routes of potential causative agents of fish-borne diseases in Taiwan as an important endemic area. Trematodes (Clonorchis, Metagonimus, Haplorchis) responsible for human liver and intestinal infection, respectively, broad fish tapeworm (Diphyllobothrium) causing diphyllobothriosis and the anisakid nematodes (e.g. Anisakis simplex) causing human anisakiosis, will serve as model parasite groups. The novelty of the project lies in its interdisciplinary character, i.e., application of different methodological approaches, e.g., morphology, ultrastructure, phylogeography, phylogenetics and molecular karyology. The project will be based on international cooperation with a key role of Slovak parasitologists experienced in multidisciplinary studies on the helminth parasites including causative agents of zoonotic diseases and fish surveys to detect their infective stages.
Duration: 1.3.2017 - 31.12.2019

Population genetics and phylogeography of invasive parasitic species
Populačná genetika a fylogeografia inváznych druhov parazitov
Program: Inter-academic agreement
Project leader: MVDr. Bazsalovicsová Eva PhD.
Duration: 1.1.2016 - 31.12.2017

Spermatologic characteristics of fish tapeworms of the order Caryophyllidea
Spermatologické charakteristiky pásomníc radu Caryophyllidea, parazitov rýb
Program: Inter-academic agreement
Project leader: RNDr. Bruňanská Magdaléna DrSc.
Duration: 1.1.2016 - 31.12.2017

Studies on the structure and dynamics of the montane natural foci of tick-borne diseases under the impact of global climate changes
Výskum štruktúry a dynamiky horského ohniska kliešťami prenášaných nákaz v podmienkach globálnych klimatických zmien
Program: Bilateral - other
Project leader: RNDr. Víchová Bronislava PhD.
Annotation:The proposed project is aimed at the research of the structure and dynamics of natural foci of vector - borne diseases in chosen model areas of central European (Slovak) and Asian Chinese) mountains under the changing global climate, environmental and socio – economic conditions. The proposed project will integrate the scientific and research potential as well as pedagogical and material-technical potential of experienced scientific institution – Institute of Parasitology SAS in Slovakia and the leading academic institution – Hebei Normal University in China. Project will create a platform for the rise of professional qualification of young scientists and PhD. students in the fields of ecology, molecular biology and genetics. The proposed project will be based on the classic field methods for collection of the ticks (flagging vegetation), collections of biological material (blood, tissues) and capture of tick's hosts, for ongoing projects of both partners as well as a basis for the future international projects with a foreign partner. An infrastructure of both partner organizations will ensure a higher added value of the research by means of exchange of experiences and introduction of new methods in the fields, molecular biology, phylogenetic, ecological parasitology, and others. It will use highly advanced methods for detection of pathogens (bacterial and protozoal) in ticks from vegetation and in the hosts. The specific hosts of individual developmental stages of ticks will be determined by the identification of mitochondrial DNA from the residual blood of a host in the ticks by the molecular biology and genetic methods (Reverse Line Blot Hybridization – “blood meal analysis”).
Duration: 1.1.2016 - 31.12.2017

The total number of projects: 12